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[卡介苗膀胱内灌注治疗膀胱癌：外周血及膀胱壁免疫细胞与疗效的关系]

[Intravesical instillation of BCG for the bladder cancer: relationship between effect and immune cells in peripheral blood and bladder wall].

作者信息

Chen L Z

机构信息

First Affiliated Hospital of Sun Yat-sen University of Medical Sciences, Guangzhou.

出版信息

Zhonghua Wai Ke Za Zhi. 1993 Jun;31(6):336-8.

PMID:8313752
Abstract

Immunohistochemical technique was used to investigate the immune cells both in the peripheral blood and the bladder wall of the bladder cancer patients before and after intravesical instillation of BCG. CD4+ and the ratio of CD4+/CD8+ in the responders were significantly higher than that in the nonresponders in peripheral blood. The immune cells of all the patients received BCG instillation were increased in the bladder wall. The CD4+/CD8+ ratio was 2.007 and 0.656 in responders and nonresponders respectively. The antitumor activity of BCG was shown by the increasing of CD4+ cells. The infiltrating degree of the immune cells would be decreased with time. It would be valuable to give maintenance treatment.

摘要

采用免疫组织化学技术研究卡介苗膀胱灌注前后膀胱癌患者外周血及膀胱壁中的免疫细胞。应答者外周血中CD4+及CD4+/CD8+比值显著高于无应答者。所有接受卡介苗灌注患者的膀胱壁中免疫细胞均增加。应答者和无应答者的CD4+/CD8+比值分别为2.007和0.656。卡介苗的抗肿瘤活性通过CD4+细胞增加得以体现。免疫细胞的浸润程度会随时间降低。进行维持治疗将具有重要价值。

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