Carapetis J R, Walker A M, Hibble M, Sriprakash K S, Currie B J
Menzies School of Health Research and Royal Darwin Hospital, Darwin, Australia.
Epidemiol Infect. 1999 Feb;122(1):59-65. doi: 10.1017/s0950268898001952.
Reports of increasing incidence and severity of invasive group A streptococcal (GAS) infections come mainly from affluent populations where exposure to GAS is relatively infrequent. We conducted a 6-year retrospective review of GAS bacteraemia in the Northern Territory of Australia, comparing the Aboriginal population (24% of the study population), who have high rates of other streptococcal infections and sequelae, to the non-Aboriginal population. Of 72 episodes, 44 (61%) were in Aboriginal patients. All 12 cases in children were Aboriginal. Risk factors were implicated in 82% of episodes (91% in adults) and there was no significant difference in the proportion of Aboriginal compared to non-Aboriginal patients with at least one risk factor. Genetic typing of isolates revealed no dominant strains and no evidence of a clone which has been a common cause of these infections elsewhere.
侵袭性A组链球菌（GAS）感染发病率和严重程度上升的报告主要来自富裕人群，在这些人群中，接触GAS的情况相对较少。我们对澳大利亚北领地的GAS菌血症进行了为期6年的回顾性研究，将原住民（占研究人群的24%）与非原住民进行比较，原住民中其他链球菌感染及其后遗症的发生率很高。在72例病例中，44例（61%）为原住民患者。所有12例儿童病例均为原住民。82%的病例（成人中为91%）存在危险因素，至少有一个危险因素的原住民患者与非原住民患者的比例没有显著差异。分离株的基因分型显示没有优势菌株，也没有证据表明存在在其他地方引起这些感染的常见克隆菌株。
