西伯利亚地区乙型肝炎病毒、丙型肝炎病毒及GB病毒-C感染的血清流行率
Seroprevalence of hepatitis B virus, hepatitis C virus and GB virus-C infections in Siberia.
作者信息
Ohba K, Mizokami M, Kato T, Ueda R, Gurtsenvitch V, Senyuta N, Syrtsev A, Zoya K, Yamashita M, Hayami M
机构信息
Second Department of Medicine, Nagoya City University Medical School, Kawasumi, Mizuho, Japan.
出版信息
Epidemiol Infect. 1999 Feb;122(1):139-43. doi: 10.1017/s0950268898001940.
We studied the seroprevalence of hepatitis B virus (HBV), hepatitis C virus (HCV) and GB virus-C (GBV-C) infections in 348 Siberian natives who lived in the Kamchatka Peninsula of Russia. Of 348 samples studied, the seroprevalence of HBsAg and anti-HBs were 11.8% (41 of 348 samples) and 35.9% (125 of 348 samples), respectively. The prevalence of HCV infection was 1.4% (5 of 348 samples), and that of GBV-C RNA, using RT-PCR methods, was 7.5% (26 of 348 samples). In Siberia, the prevalences of HBV and GBV-C infections were about tenfold higher than those in Japan. The prevalence of HBsAg in subjects under 50 years of age was significantly higher than that in those over 50 years old (P < 0.05). Because HBV infection is highly endemic in Siberia, we propose that the community-based mass immunization must be conducted as soon as possible in this area.
我们研究了居住在俄罗斯堪察加半岛的348名西伯利亚原住民中乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）和GB病毒C型（GBV-C）感染的血清流行率。在所研究的348份样本中，HBsAg和抗-HBs的血清流行率分别为11.8%（348份样本中的41份）和35.9%（348份样本中的125份）。HCV感染率为1.4%（348份样本中的5份），采用逆转录聚合酶链反应（RT-PCR）方法检测GBV-C RNA的感染率为7.5%（348份样本中的26份）。在西伯利亚，HBV和GBV-C感染率比日本高出约10倍。50岁以下人群的HBsAg流行率显著高于50岁以上人群（P<0.05）。由于HBV感染在西伯利亚高度流行，我们建议该地区应尽快开展基于社区的大规模免疫接种。
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