Mills R D, Sethia K K
The Norfolk and Norwich Hospital, UK.
Int J Impot Res. 1999 Feb;11(1):29-32; discussion 33-4. doi: 10.1038/sj.ijir.3900379.
The aim of this study was to assess whether redosing with a combination of intracavernosal (IC) vasoactive agents could produce a complete erectile response, thereby providing a reliable and reproducible method of dynamic investigation of erectile dysfunction. Forty-one impotent men were redosed with a combination intracavernosal agents until a constant penile rigidity was achieved. They were then shown audiovisual sexual stimulation (VES) by means of a videotape. The erectile responses were monitored continuously by RigiScan (Dacomed).
Despite a constant rigidity with intracavernous injection (ICI), 16 men (39%) still had an improved response with VES that was clinically detectable.
Dynamic investigation of erectile dysfunction with a combination and redosing of IC agents may still lead to an incomplete erectile response. This may potentially lead to patients being incorrectly labelled and confirms the limitations of follow-up studies using dynamic tests of erectile function.
本研究的目的是评估阴茎海绵体内(IC)血管活性药物联合再次给药是否能产生完全勃起反应,从而提供一种可靠且可重复的勃起功能障碍动态研究方法。41名阳痿男性接受阴茎海绵体内联合药物再次给药,直至达到恒定的阴茎硬度。然后通过录像带向他们展示视听性刺激(VES)。勃起反应通过RigiScan(Dacomed)持续监测。
尽管阴茎海绵体内注射(ICI)后硬度恒定,但16名男性(39%)在VES刺激下仍有临床上可检测到的改善反应。
使用IC药物联合及再次给药对勃起功能障碍进行动态研究仍可能导致不完全勃起反应。这可能会导致患者被错误分类,并证实了使用勃起功能动态测试的随访研究的局限性。