前列腺素E1联合酚妥拉明治疗勃起功能障碍
Prostaglandin E1 with phentolamine for the treatment of erectile dysfunction.
作者信息
Meinhardt W, de la Fuente R B, Lycklama à Nijeholt A A, Vermeij P, Zwartendijk J
机构信息
Academic Hospital Leiden, Urology Department and Pharmacy, The Netherlands.
出版信息
Int J Impot Res. 1996 Mar;8(1):5-7.
AIM OF THE STUDY
to evaluate the feasibility of a self-injection programme for impotence with a combination of 10 micrograms prostaglandine E1 (PGE1) and 0.5 mg phentolamine.
METHOD
follow-up at outpatients department with history taking, physical examination and questionnaires of 58 patients using this combination. Many patients could compare this drug combination with previously used drugs for intracavernous use.
RESULTS
42 patients started regular use. After a follow-up of 14 months, 26 are still on the programme. Drug related problems encountered: 10 patients reported insufficient erectile response, five patients have had priapism, four patients experienced severe pain, one patient developed fibrosis.
CONCLUSION
the combination of PGE1 and phentolamine is very effective. The complication rate is comparable with those reported from PGE1 alone and from papaverine with phentolamine.
研究目的
评估采用10微克前列腺素E1（PGE1）与0.5毫克酚妥拉明联合用药的自我注射方案治疗阳痿的可行性。
方法
在门诊对58例使用该联合用药方案的患者进行随访，包括病史采集、体格检查及问卷调查。许多患者可将此联合用药与先前用于海绵体内注射的药物进行比较。
结果
42例患者开始规律用药。随访14个月后，26例仍在该方案治疗中。出现的与药物相关的问题：10例患者报告勃起反应不足，5例患者发生阴茎异常勃起，4例患者经历严重疼痛，1例患者出现纤维化。
结论
PGE1与酚妥拉明联合用药非常有效。并发症发生率与单独使用PGE1以及罂粟碱与酚妥拉明联合用药所报告的发生率相当。
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