Czakó L, Nagy E, Szilágyi I, László F A
Endokrinologie. 1976;68(2):235-8.
The effect of clofibrate on the water metabolism was studied in rats with pituitary stalk lesion. It was found that this drug made the oliguria interphase much more marked and more prolonged. In rats anaesthetized with alcohol, clofibrate pre-treatment led to an enhancement of the effect of ADH. The experiments permit the conclusion that the presence of endogenous ADH is necessary for clofibrate antidiuresis. Its effect is presumably exerted via the mobilization of the ADH, but it can not be excluede that it also enhances the peripheral effect of ADH.
在患有垂体柄损伤的大鼠中研究了氯贝丁酯对水代谢的影响。发现该药物使少尿间期更加明显且持续时间更长。在用酒精麻醉的大鼠中，氯贝丁酯预处理导致抗利尿激素（ADH）的作用增强。这些实验得出的结论是，内源性ADH的存在是氯贝丁酯产生抗利尿作用所必需的。其作用可能是通过动员ADH发挥的，但也不能排除它还增强了ADH的外周作用。
