Czakó L, Nagy E, László F A
Acta Physiol Acad Sci Hung. 1977;49(2):177-83.
A study was made of the effect of chlorpropamide in rats with pituitary stalk lesion. It was found that the drug made the oliguric interphase more pronounced and protracted, while in the lasting polyuric phase in the absence of endogenous ADH it influenced water intake only moderately. Enhancement of the effect of exogenous ADH was observed after a 2-day chlorpropamide pretreatment. The results support the view that the presence of a small amount of endogenous ADH is necessary for chlorpropamide-antidiuresis. The drug presumably brings about the decrease in diuresis via ADH mobilization, but its peripheral effect is also enhanced.
对患有垂体柄损伤的大鼠进行了氯磺丙脲作用的研究。发现该药物使少尿间期更加明显和延长，而在缺乏内源性抗利尿激素（ADH）的持续多尿期，它对水摄入的影响仅为中度。在进行2天的氯磺丙脲预处理后，观察到外源性ADH作用增强。这些结果支持了这样一种观点，即少量内源性ADH的存在对于氯磺丙脲的抗利尿作用是必要的。该药物可能通过动员ADH导致利尿减少，但其外周作用也得到增强。
