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关于丙戊酸的毒性

On the toxicity of valproic-acid.

作者信息

Moreiras Plaza M, Rodríguez Goyanes G, Cuiña L, Alonso R

机构信息

Department of Nephrology, Xeral-Cies Hospital, Vigo, Spain.

出版信息

Clin Nephrol. 1999 Mar;51(3):187-9.

PMID:10099893
Abstract

Pancreatitis is a serious adverse effect of valproic acid (VPA). We report a case of VPA-induced pancreatitis in a dialysis patient. A brief review concerning VPA toxicity and acute pancreatitis in chronic renal patients is presented. We suggest that end-stage renal disease (ESRD) should be considered another risk factor for VPA-induced pancreatitis.

摘要

胰腺炎是丙戊酸(VPA)的一种严重不良反应。我们报告了一例透析患者发生VPA诱导的胰腺炎病例。本文对慢性肾病患者中VPA毒性和急性胰腺炎进行了简要综述。我们认为终末期肾病(ESRD)应被视为VPA诱导胰腺炎的另一个危险因素。

相似文献

1
On the toxicity of valproic-acid.关于丙戊酸的毒性
Clin Nephrol. 1999 Mar;51(3):187-9.
2
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Eur J Paediatr Neurol. 2008 Mar;12(2):141-3. doi: 10.1016/j.ejpn.2007.07.006. Epub 2007 Sep 18.
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A case of valproic acid-induced acute pancreatitis in tuberous sclerosis coexisting with end-stage renal disease.一例结节性硬化症合并终末期肾病患者服用丙戊酸后引发的急性胰腺炎。
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Pancreatitis, complicated by a pancreatic pseudocyst associated with the use of valproic acid.胰腺炎,并发与使用丙戊酸相关的胰腺假性囊肿。
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Development of acute pancreatitis caused by sodium valproate in a patient with bipolar disorder on hemodialysis for chronic renal failure: a case report.一例慢性肾衰竭接受血液透析的双相情感障碍患者因丙戊酸钠导致急性胰腺炎:病例报告
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[Acute pancreatitis caused by valproic acid: apropos a case].丙戊酸所致急性胰腺炎:附1例报告
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[Fatal necro-hemorrhagic pancreatitis related to sodium valproate: case report].[与丙戊酸钠相关的致死性坏死性出血性胰腺炎:病例报告]
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Pancreatitis in children on chronic dialysis treated with valproic acid.
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引用本文的文献

1
Valproic Acid-Associated Acute Pancreatitis: Systematic Literature Review.丙戊酸相关性急性胰腺炎:系统文献综述
J Clin Med. 2023 Sep 19;12(18):6044. doi: 10.3390/jcm12186044.
2
Drug induced pancreatitis: A systematic review of case reports to determine potential drug associations.药物性胰腺炎:病例报告的系统回顾,以确定潜在的药物关联性。
PLoS One. 2020 Apr 17;15(4):e0231883. doi: 10.1371/journal.pone.0231883. eCollection 2020.
3
Acute Pancreatitis in a Patient with Subarachnoid Hemorrhage: A Causal Link or a Mere Coincidence?
一名蛛网膜下腔出血患者并发急性胰腺炎:因果关联还是纯属巧合?
Indian J Crit Care Med. 2020 Feb;24(2):141-142. doi: 10.5005/jp-journals-10071-23348.
4
Development of acute pancreatitis caused by sodium valproate in a patient with bipolar disorder on hemodialysis for chronic renal failure: a case report.一例慢性肾衰竭接受血液透析的双相情感障碍患者因丙戊酸钠导致急性胰腺炎:病例报告
BMC Psychiatry. 2014 Mar 29;14:93. doi: 10.1186/1471-244X-14-93.
5
Case files of the Children's Hospital of Michigan Regional Poison Control Center: the use of carnitine for the management of acute valproic acid toxicity.密歇根儿童医院区域中毒控制中心病例档案:肉碱在急性丙戊酸中毒治疗中的应用
J Med Toxicol. 2007 Sep;3(3):129-38. doi: 10.1007/BF03160923.
6
Valproic acid-induced pancreatitis.
J Gastroenterol. 2007 Jul;42(7):598-9. doi: 10.1007/s00535-007-2062-8. Epub 2007 Jul 25.
7
Valproate as a mainstay of therapy for pediatric epilepsy.丙戊酸盐作为小儿癫痫治疗的主要药物。
Paediatr Drugs. 2006;8(2):113-29. doi: 10.2165/00148581-200608020-00004.
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Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience.丙戊酸盐的药理和治疗特性:35年临床经验总结
CNS Drugs. 2002;16(10):695-714. doi: 10.2165/00023210-200216100-00004.