Parker P H, Helinek G L, Ghishan F K, Greene H L
Gastroenterology. 1981 Apr;80(4):826-8.
Valproic acid represents a new class of anticonvulsants that are widely employed in the management of many types of seizure disorders. Compared with other anticonvulsants, it has been considered relatively free of adverse effects. Recently, acute hepatic failure has been ascribed to valproic acid. Now experience is accumulating that implicates this agent in causing pancreatitis. Contributing to this evidence, the patient described herein had well-documented, recurrent pancreatitis while he was taking valproic acid. Nonspecific vomiting and abdominal pain frequently occur with valproic acid; however, pancreatitis must be considered whenever these symptoms are severe or protracted.
丙戊酸是一类新型抗惊厥药，广泛用于多种癫痫发作性疾病的治疗。与其他抗惊厥药相比，它被认为不良反应相对较少。最近，已有急性肝衰竭归因于丙戊酸。目前，越来越多的经验表明该药物可导致胰腺炎。支持这一证据的是，本文所述患者在服用丙戊酸期间患有有充分记录的复发性胰腺炎。丙戊酸常伴有非特异性呕吐和腹痛；然而，每当这些症状严重或持续时，都必须考虑胰腺炎的可能。
