Putzke H P, Persaud T V
Exp Pathol (Jena). 1976;12(6):329-35. doi: 10.1016/s0014-4908(76)80008-7.
Veno-occlusive disease of the liver is caused by the hepatotoxic pyrrolizidine alkaloid fulvine which is found in the plant Crotolaria fulva. Histological, histochemical and electronmicroscopic studies carried out in Wistar rats showed that an aqueous solution of fulvine produced an acute pancreatopathy with interstitial oedema and secondary hypoxic dystrophy of the acinar cells, when administered at doses of 10 and 20 mg/kg body weight.
肝静脉闭塞病是由存在于黄花猪屎豆植物中的肝毒性吡咯里西啶生物碱富尔文引起的。在Wistar大鼠身上进行的组织学、组织化学和电子显微镜研究表明，当以10和20毫克/千克体重的剂量给药时，富尔文水溶液会导致急性胰腺炎，伴有间质水肿和腺泡细胞继发性缺氧性营养不良。
