Arseculeratne S N, Gunatilaka A A, Panabokke R G
J Ethnopharmacol. 1985 Jul;13(3):323-35. doi: 10.1016/0378-8741(85)90078-9.
Seventy five medicinal plants of the traditional Ayurvedic pharmacopoeia of Sri Lanka have been screened chemically for alkaloids and pyrrolizidine alkaloids. Of these, Crotolaria juncea L. was found to contain pyrrolizidine alkaloids with biological effects consistent with pyrrolizidine alkaloid toxicity. Feeding trials in rats with three plants lacking pyrrolizidine alkaloids, namely Aegle marmelos (L.) Corr., Hemidesmus indicus (L.) Ait. F. and Terminalia chebula Retz. produced hepatic lesions which included central vein abnormalities while Terminalia chebula and Withania somnifera (L.) dunal produced marked renal lesions.
对斯里兰卡传统阿育吠陀药典中的75种药用植物进行了生物碱和吡咯里西啶生物碱的化学筛选。其中，发现菽麻含有吡咯里西啶生物碱，其生物效应与吡咯里西啶生物碱毒性一致。对三种不含吡咯里西啶生物碱的植物进行大鼠喂养试验，这三种植物分别是印度枳椇、印度牛弭和诃子，结果产生了肝脏病变，包括中央静脉异常，而诃子和印度人参则产生了明显的肾脏病变。
