Lee S R, Cheun J K
Department of Pharmacology, School of Medicine, Keimyung University, Taegu, Korea.
Neurol Res. 1999 Mar;21(2):225-8. doi: 10.1080/01616412.1999.11740922.
The goal of this study was to determine whether propofol has protective effect against kainic acid (KA)-induced excitotoxicity. Administration of propofol (25 mg kg-1 i.p.) was done 2 h before KA (10 mg kg-1 i.p.), immediately after, and 2 h, 4 h, 6 h, and 12 h after the KA, and twice daily for an additional three days. Neuronal cell death in CA1 and CA3 subsector of hippocampus was evaluated quantitatively four days after KA. The KA and propofol-injected rats had a greater number of surviving neuronal cells than did KA (and vehicle)-injected rats. Our results suggest that propofol holds potential for the protection of neuronal cells against KA induced excitotoxicity.
本研究的目的是确定丙泊酚是否对 kainic 酸（KA）诱导的兴奋性毒性具有保护作用。在 KA（腹腔注射 10 mg/kg）前 2 小时、注射后立即、注射后 2 小时、4 小时、6 小时和 12 小时腹腔注射丙泊酚（25 mg/kg），并在接下来的三天每天注射两次。在 KA 注射四天后，定量评估海马体 CA1 和 CA3 亚区的神经元细胞死亡情况。与注射 KA（和溶剂）的大鼠相比，注射 KA 和丙泊酚的大鼠存活的神经元细胞数量更多。我们的结果表明，丙泊酚具有保护神经元细胞免受 KA 诱导的兴奋性毒性的潜力。
