Bartal A, Bentwich Z, Manny N, Izak G
Acta Haematol. 1978;60(3):161-71. doi: 10.1159/000207712.
The ethnic distribution of 288 patients with chronic lymphocytic leukemia (CLL) from five medical centers in Israel during the decade 1960--1970 was investigated as well as other features of the disease. 80.5% of the patients were of East European descent, 14.5% originated from Asia and Africa and 5% were born in Israel. Based on the ethnic distribution of the elderly population of Israel during the above period, it is suggested that CLL occurs more frequently in European-born Jews than in Asian and African Jews. A low occurrence of Coombs positive hemolytic anemia was revealed, amounting to 7.2% of the patients. Of 68 patients who underwent serum immunoglobulin studies, up to 74% exhibited deficiency of at least one type of immunoglobulin. Low levels of IgA were encountered in 61.2%, IgM in 51.5% and IgG in 29.5% of the patients. 26 of 206 patients with CLL (12.5%), all of East European origin, had an additional primary malignant tumor, cancer of the skin and breast being the most frequent associated malignancies. In 6 patients of the 26, two additional neoplasms were diagnosed. Hypogammaglobulinemia was more frequent in patients with additional primary malignant tumors and in patients with advanced disease. The possible causes for the ethnic distribution of CLL in Israil as well as of other tumors are discussed.
对1960年至1970年期间来自以色列五个医疗中心的288例慢性淋巴细胞白血病（CLL）患者的种族分布以及该疾病的其他特征进行了调查。80.5%的患者为东欧血统，14.5%来自亚洲和非洲，5%出生在以色列。根据上述时期以色列老年人口的种族分布情况，提示欧洲出生的犹太人患CLL的频率高于亚洲和非洲的犹太人。发现Coombs阳性溶血性贫血的发生率较低，占患者的7.2%。在68例接受血清免疫球蛋白研究的患者中，高达74%的患者至少有一种免疫球蛋白缺乏。61.2%的患者IgA水平低，51.5%的患者IgM水平低，29.5%的患者IgG水平低。206例CLL患者中有26例（12.5%），均为东欧血统，患有另一种原发性恶性肿瘤，皮肤癌和乳腺癌是最常见的相关恶性肿瘤。在这26例患者中的6例中，又诊断出另外两种肿瘤。低丙种球蛋白血症在患有另一种原发性恶性肿瘤的患者和晚期疾病患者中更为常见。文中讨论了以色列CLL以及其他肿瘤种族分布的可能原因。
