Lishner M, Prokocimer M, Ron E, Shaklai M
Division of Hematology, Beilinson Medical Center, Petah Tiqva, Israel.
Postgrad Med J. 1987 Apr;63(738):253-6. doi: 10.1136/pgmj.63.738.253.
The relationship between chronic lymphocytic leukaemia (CLL) and primary malignant neoplasms was evaluated using data from the Hematology Division in Beilinson Medical Center and the Israel Cancer Registry. The study population consisted of 81 patients diagnosed between 1962 and 1984. A total of 16 patients were found to have 21 malignant neoplasms in addition to their CLL. Excluding patients with nonmelanoma skin tumours, a 1.7 increased risk (statistically not significant) for developing second malignant neoplasms in CLL patients was detected. The only tumour which occurred significantly more than expected subsequent to CLL diagnosis was brain cancer. The coexistence of multiple cancers in the same patient was diagnosed in four of the patients. The results of this study further support the hypothesis that patients with CLL are prone to develop second neoplasms.
利用贝林森医疗中心血液科的数据和以色列癌症登记处的数据，对慢性淋巴细胞白血病（CLL）与原发性恶性肿瘤之间的关系进行了评估。研究人群包括1962年至1984年间确诊的81例患者。共有16例患者除患有CLL外，还患有21种恶性肿瘤。排除非黑色素瘤皮肤肿瘤患者后，发现CLL患者发生第二原发性恶性肿瘤的风险增加了1.7倍（无统计学意义）。CLL诊断后显著高于预期发生的唯一肿瘤是脑癌。在4例患者中诊断出同一患者存在多种癌症并存的情况。这项研究的结果进一步支持了CLL患者易于发生第二肿瘤的假说。
