Basili S, Vieri M, Di Lecce V N, Maccioni D, Marmifero M, Paradiso M, Labbadia G, Spada S, Cordova C, Alessandri C
Dipartimento di Terapia Medica, Università La Sapienza, Rome, Italy.
Clin Ter. 1998 Nov-Dec;149(6):413-7.
Several epidemiological and clinical reports have investigated the relationship between Helicobacter pylori (H. pylori) infection and ischemic heart disease (IHD). All studies utilized for the diagnosis of H. pylori infection the antibody titre that is unable to distinguish an actual from a previous H. pylori infection.
We report a retrospective analysis on 149 subjects, who underwent an esophago-gastro-duodenoscopy, in whom the search for H. pylori was histologically performed.
The prevalence of IHD is not significantly different from that observed in H. pylori free patients (26% vs 21%, p = 0.527).
The mechanism underlying the possible role of H. pylori needs further investigation and prospective studies to further analyze the relationship between "active" H. pylori infection and ischemic heart disease were necessary.
多项流行病学和临床报告研究了幽门螺杆菌（H. pylori）感染与缺血性心脏病（IHD）之间的关系。所有用于诊断幽门螺杆菌感染的研究均采用抗体滴度，而该指标无法区分当前与既往的幽门螺杆菌感染。
我们报告了一项对149例接受食管-胃-十二指肠镜检查的患者进行的回顾性分析，这些患者均接受了幽门螺杆菌的组织学检测。
缺血性心脏病的患病率与未感染幽门螺杆菌的患者相比无显著差异（26% 对21%，p = 0.527）。
幽门螺杆菌可能发挥作用的潜在机制需要进一步研究，有必要开展前瞻性研究以进一步分析“现症”幽门螺杆菌感染与缺血性心脏病之间的关系。
