DeLord C, Treleaven J, Shepherd J, Saso R, Powles R L
Department of Haematology, The Royal Marsden NHS Trust, Sutton, UK.
Bone Marrow Transplant. 1999 Mar;23(5):523-5. doi: 10.1038/sj.bmt.1701603.
We report the unusual complication of vaginal stenosis occurring after allogeneic bone marrow transplantation (BMT) for leukaemia. This was in all likelihood a manifestation of chronic graft-versus-host disease (cGVHD), although the patient has no other stigmata of this and suffered little acute graft-versus-host disease (aGVHD) after BMT. Other risk factors for vaginal stenosis were considered and appear to be absent in this patient, although the total body irradiation used as part of her conditioning therapy may play a role. We suggest that vaginal stenosis may be under-reported, since female patients suffer a number of gynaecological complications after BMT, and that regular questioning and examination may aid in making an earlier diagnosis, allowing speedier instigation of therapy and thus improving quality of life.
我们报告了1例白血病患者在接受异基因骨髓移植（BMT）后出现阴道狭窄这一罕见并发症。这很可能是慢性移植物抗宿主病（cGVHD）的一种表现，尽管该患者并无其他相关体征，且在BMT后很少发生急性移植物抗宿主病（aGVHD）。我们考虑了导致阴道狭窄的其他风险因素，该患者似乎不存在这些因素，不过其预处理方案中使用的全身照射可能起到了一定作用。我们认为，阴道狭窄可能未得到充分报告，因为女性患者在BMT后会出现多种妇科并发症，定期询问和检查可能有助于早期诊断，从而能更快地启动治疗，进而改善生活质量。
