Park Junsik, Kim Tae-Hee, Lee Hae-Hyeog, Chung Soo-Ho, Lee Daegeun
Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, Bucheon, Korea.
Obstet Gynecol Sci. 2013 Jul;56(4):277-80. doi: 10.5468/ogs.2013.56.4.277. Epub 2013 Jul 15.
Allogenic peripheral blood stem cell transplantation (Allo-PBSCT) is being used to treat hematological malignancies with increasing frequency. Graft-versus-host disease (GvHD) is a complex complication of PBSCT. A 43-year-old woman came to the gynecology clinic for amenorrhea. She had been diagnosed with acute myeloid leukemia 2 years earlier and treated with induction and consolidation chemotherapy. After developing complete remission, she underwent Allo-PBSCT. When she started chemotherapy, her menstrual cycle completely disappeared. Fourteen months after menopausal hormone replacement therapy, it was discovered that her upper vaginal canal was completely obstructed. The lower vagina had an atrophic appearance. We report a rare case of partial vaginal obstruction as a complication of chronic GvHD and review the literature. We expect that this case report provides an opportunity to remind clinician of the gynecologic complications of GvHD.
异基因外周血干细胞移植（Allo-PBSCT）正越来越频繁地用于治疗血液系统恶性肿瘤。移植物抗宿主病（GvHD）是外周血干细胞移植的一种复杂并发症。一名43岁女性因闭经前来妇科门诊就诊。她两年前被诊断为急性髓系白血病，并接受了诱导和巩固化疗。在达到完全缓解后，她接受了异基因外周血干细胞移植。开始化疗时，她的月经周期完全消失。绝经激素替代治疗14个月后，发现她的阴道上段完全阻塞。阴道下段呈萎缩外观。我们报告一例罕见的慢性移植物抗宿主病并发症导致部分阴道阻塞的病例，并复习相关文献。我们希望本病例报告能为提醒临床医生注意移植物抗宿主病的妇科并发症提供契机。
