Callebaut I, Courvalin J C, Mornon J P
Systèmes moléculaires and Biologie structurale, LMCP, CNRS UMR 7590, Université Paris 6, France.
FEBS Lett. 1999 Mar 5;446(1):189-93. doi: 10.1016/s0014-5793(99)00132-5.
Using sensitive methods of sequence analysis including hydrophobic cluster analysis, we report here a hitherto undescribed family of modules, the BAH (bromo-adjacent homology) family, which includes proteins such as eukaryotic DNA (cytosine-5) methyltransferases, the origin recognition complex 1 (Orc1) proteins, as well as several proteins involved in transcriptional regulation. The BAH domain appears to act as a protein-protein interaction module specialized in gene silencing, as suggested for example by its interaction within yeast Orc1p with the silent information regulator Sir1p. The BAH module might therefore play an important role by linking DNA methylation, replication and transcriptional regulation.
利用包括疏水簇分析在内的敏感序列分析方法，我们在此报告了一个迄今未被描述的模块家族——BAH（溴相邻同源性）家族，该家族包括真核DNA（胞嘧啶-5）甲基转移酶、起源识别复合物1（Orc1）蛋白等蛋白质，以及几种参与转录调控的蛋白质。BAH结构域似乎作为一种专门用于基因沉默的蛋白质-蛋白质相互作用模块，例如，它在酵母Orc1p中与沉默信息调节因子Sir1p的相互作用就表明了这一点。因此，BAH模块可能通过连接DNA甲基化、复制和转录调控发挥重要作用。
