大鼠生长停滞和DNA损伤诱导蛋白45γ的分子克隆、基因诱导及其在神经元细胞死亡中的作用
Molecular cloning of rat GADD45gamma, gene induction and its role during neuronal cell death.
作者信息
Kojima S, Mayumi-Matsuda K, Suzuki H, Sakata T
机构信息
Shionogi Institute for Medical Science, Osaka, Japan.
出版信息
FEBS Lett. 1999 Mar 12;446(2-3):313-7. doi: 10.1016/s0014-5793(99)00234-3.
To study the molecular mechanism of neuronal cell death, we carried out the screening of genes which were induced during the neuronal cell death of neuronal PC12. We cloned the cDNA of rat GADD45gamma, the third member of the GADD45 family. Induction of GADD45gamma mRNA was observed in the neuronal cell death caused by depletion of neurotrophic factor and Ca2+ ionophore treatment. Overexpression of GADD45gamma in superior cervical ganglion neurons caused cell death. These results suggest that GADD45gamma plays an important role in neuronal cell death.
为研究神经元细胞死亡的分子机制，我们对在神经元PC12细胞死亡过程中被诱导的基因进行了筛选。我们克隆了大鼠GADD45γ的cDNA，它是GADD45家族的第三个成员。在神经营养因子耗竭和Ca2+离子载体处理引起的神经元细胞死亡中观察到了GADD45γ mRNA的诱导。GADD45γ在上颈神经节神经元中的过表达导致细胞死亡。这些结果表明GADD45γ在神经元细胞死亡中起重要作用。
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