[多次给予氢化可的松对大鼠大脑皮质切片中22Na动力学的影响]
[Effect of multiple hydrocortisone administrations on the kinetics of 22Na in slices of rat cerebral cortex].
作者信息
Garina I A, Emel'ianov N A
出版信息
Fiziol Zh SSSR Im I M Sechenova. 1976 Sep;62(9):1373-7.
The dynamics of 22-Na efflux from slices of rat brain cortex incubated in McIlwains medium was studied with the aid of improved compartmental analysis. Hydrocortisone (HC) was injected during 8 days. The isotope efflux followed 3-exponential kinetics. The kinetic analysis was made on the basis of 3-compartmental models of Na exchange. Administration of HC decreased the content of Na in fast-exchanged (extracellular) fraction and increased its content in the slow-exchanged (intracellular) fractions. HC elevated the speed constants of intercompartmental Na flows for intracellular fractions, especially the influx constants. The values of stationary Na flows between extra- and intracellular compartments were significantly increased. The data obtained are discussed with regard to direct action of HC on ionic exchange in tissue.
借助改进的房室分析方法，研究了在麦基尔韦恩氏培养基中孵育的大鼠大脑皮层切片中22 - 钠流出的动力学。氢化可的松（HC）注射8天。同位素流出遵循三指数动力学。动力学分析基于钠交换的三室模型进行。HC的给药降低了快速交换（细胞外）部分中钠的含量，并增加了其在缓慢交换（细胞内）部分中的含量。HC提高了细胞内部分间钠流动的速度常数，尤其是流入常数。细胞外和细胞内隔室之间的稳态钠流量值显著增加。结合HC对组织中离子交换的直接作用对所得数据进行了讨论。
Zotero 插件