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[氢化可的松对电刺激后大鼠大脑皮质切片中钠和钾分布的影响]

[Effect of hydrocortisone on sodium and potassium distribution in the sections of the cerebral cortex of rats after their electric stimulation].

作者信息

Emelianov N A

出版信息

Probl Endokrinol (Mosk). 1976 Jul-Aug;22(4):82-6.

PMID:1028045
Abstract

Sections of the rat brain cortex were incubated in various physiological media using container-electrodes, similar to the McIlwain's type. The shifts of sodium and potassium distribution between the extra- and intracellular spaces of the slices after different stimulation parameters and the subsequent restoration were measured. The administration of hydrocortisone (for 7 days, 5 mg/100 g daily) usually increased the response of the slices to the stimulation in incubation in the glutamate devoid medium. When 0.2--0.5 mM of glutamate was added to the media the effect of hydrocortisone disappeared. Possible physiological significance of the mentioned results is discussed.

摘要

使用类似于麦基尔韦恩型的容器电极,将大鼠大脑皮层切片置于各种生理介质中进行孵育。测量了在不同刺激参数作用下以及随后恢复过程中,切片细胞外和细胞内空间之间钠和钾分布的变化。给予氢化可的松(连续7天,每日5mg/100g)通常会增强切片在不含谷氨酸的介质中孵育时对刺激的反应。当向介质中添加0.2 - 0.5mM的谷氨酸时,氢化可的松的作用消失。文中讨论了上述结果可能的生理意义。

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