Barduagni P, Schwartz U, Nyamayaro W, Chauke T L
Mashonaland West Ministry of Health and Child Welfare, Zimbabwe/Italian Cooperation.
Cent Afr J Med. 1998 Oct;44(10):251-4.
To detect the level of the in vivo chloroquine efficacy in falciparum malaria infections, in order to assess the need for change in the management and treatment of uncomplicated malaria.
Prospective descriptive study.
Chirundu Rural Clinic, Mashonaland West Province.
63 patients confirmed by a positive blood slide for P. falciparum who attended Chirundu clinic, who were eligible for the study and, who also agreed to participate.
MAIN OUTCOME MEASURE(S): Frequency of treatment success, early treatment failure and late treatment failure in uncomplicated patients treated with chloroquine.
Out of 63 cases enrolled and completely followed up, chloroquine treatment was effective in 54 cases (85.7%) and was not effective in nine cases (14.3%). All treatment failures were successfully treated with sulphadoxine + pyrimethamine (Fansidar) or quinine following the approved guidelines.
Chloroquine remains highly effective in the treatment of malaria due to P. falciparum in the Zambezi Valley of Hurungwe district and therefore, has to remain the first line drug. Likewise, guidelines for the use of sulphadoxine + pyrimethamine (Fansidar) or quinine as second line drugs, are adequate to the local situation. Health workers directly supervised the patients when they were swallowing the tablets during the whole course, and this without doubt, indirectly increased the efficacy of chloroquine. It is vital to confirm the malaria diagnosis on the spot appointing microscopists or distributing a limited stock of Parasight-F test.
检测体内氯喹对恶性疟原虫感染的疗效水平，以评估单纯性疟疾管理和治疗方案改变的必要性。
前瞻性描述性研究。
西马绍纳兰省奇伦杜农村诊所。
63例经血涂片确诊为恶性疟原虫阳性、符合研究条件且同意参与的奇伦杜诊所就诊患者。
氯喹治疗单纯性患者的治疗成功率、早期治疗失败率和晚期治疗失败率。
63例纳入并完成随访的病例中，氯喹治疗有效54例（85.7%），无效9例（14.3%）。所有治疗失败病例均按照批准的指南成功采用磺胺多辛+乙胺嘧啶（Fansidar）或奎宁进行了治疗。
在胡伦圭区赞比西河谷，氯喹对恶性疟原虫所致疟疾仍具有高效，因此必须保留为一线用药。同样，将磺胺多辛+乙胺嘧啶（Fansidar）或奎宁作为二线用药的指南也符合当地情况。在整个疗程中，卫生工作者直接监督患者吞服片剂，这无疑间接提高了氯喹的疗效。当场确诊疟疾至关重要，可指定显微镜检查人员或分发少量Parasight - F检测试剂。
