疟原虫耐药性的历史、动态变化及公共卫生重要性。
History, dynamics, and public health importance of malaria parasite resistance.
作者信息
Talisuna Ambrose O, Bloland Peter, D'Alessandro Umberto
机构信息
Ministry of Health, Epidemiological Surveillance Division, Kampala, Uganda.
出版信息
Clin Microbiol Rev. 2004 Jan;17(1):235-54. doi: 10.1128/CMR.17.1.235-254.2004.
Abstract
Despite considerable efforts, malaria is still one of the most devastating infectious diseases in the tropics. The rapid spread of antimalarial drug resistance currently compounds this grim picture. In this paper, we review the history of antimalarial drug resistance and the methods for monitoring it and assess the current magnitude and burden of parasite resistance to two commonly used drugs: chloroquine and sulfadoxine-pyrimethamine. Furthermore, we review the factors involved in the emergence and spread of drug resistance and highlight its public health importance. Finally, we discuss ways of dealing with such a problem by using combination therapy and suggest some of the research themes needing urgent answers.
摘要
尽管付出了巨大努力，但疟疾仍是热带地区最具毁灭性的传染病之一。目前，抗疟药物耐药性的迅速传播使这一严峻形势更加复杂。在本文中，我们回顾了抗疟药物耐药性的历史及其监测方法，并评估了目前疟原虫对两种常用药物——氯喹和磺胺多辛-乙胺嘧啶的耐药程度及负担。此外，我们还回顾了耐药性产生和传播所涉及的因素，并强调了其对公共卫生的重要性。最后，我们讨论了通过联合疗法应对这一问题的方法，并提出了一些亟待解答的研究主题。
相似文献
1
History, dynamics, and public health importance of malaria parasite resistance.疟原虫耐药性的历史、动态变化及公共卫生重要性。
Clin Microbiol Rev. 2004 Jan;17(1):235-54. doi: 10.1128/CMR.17.1.235-254.2004.
2
Monitoring the drug-sensitivity of Plasmodium falciparum in coastal towns in Madagascar by use of in vitro chemosensitivity and mutation detection tests.通过体外化学敏感性和突变检测试验监测马达加斯加沿海城镇恶性疟原虫的药物敏感性。
Parasite. 2002 Sep;9(3):247-53. doi: 10.1051/parasite/2002093247.
3
Declining chloroquine resistance of Plasmodium falciparum in Lambaréné, Gabon from 1992 to 1998.1992年至1998年加蓬兰巴雷内恶性疟原虫对氯喹耐药性的下降情况
Wien Klin Wochenschr. 2001 Jan 15;113(1-2):63-4.
4
Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next?恶性疟原虫对乙胺嘧啶-磺胺多辛的耐药性：接下来该怎么办？
Trends Parasitol. 2001 Dec;17(12):582-8. doi: 10.1016/s1471-4922(01)02085-2.
5
The origins of antimalarial drug resistance.抗疟药物耐药性的起源。
Trends Parasitol. 2004 Nov;20(11):512-8. doi: 10.1016/j.pt.2004.08.006.
6
Assessment of therapeutic response of Plasmodium falciparum to chloroquine and sulfadoxine-pyrimethamine in an area of low malaria transmission in Colombia.在哥伦比亚疟疾低传播地区对恶性疟原虫对氯喹和磺胺多辛-乙胺嘧啶治疗反应的评估。
Am J Trop Med Hyg. 1999 Dec;61(6):968-72. doi: 10.4269/ajtmh.1999.61.968.
7
Rapid dissemination of Plasmodium falciparum drug resistance despite strictly controlled antimalarial use.尽管严格控制抗疟药物的使用，但恶性疟原虫的耐药性仍迅速传播。
PLoS One. 2007 Jan 3;2(1):e139. doi: 10.1371/journal.pone.0000139.
8
Chloroquine-resistant Plasmodium falciparum local strain in Taiz Governorate, Republic of Yemen.也门共和国塔伊兹省的耐氯喹恶性疟原虫本地菌株。
Chemotherapy. 2006;52(4):166-70. doi: 10.1159/000093592. Epub 2006 May 24.
9
Elucidating Mechanisms of Drug-Resistant Plasmodium falciparum.阐明耐药性疟原虫的作用机制。
Cell Host Microbe. 2019 Jul 10;26(1):35-47. doi: 10.1016/j.chom.2019.06.001.
10
Therapy of uncomplicated falciparum malaria: a randomized trial comparing artesunate plus sulfadoxine-pyrimethamine versus sulfadoxine-pyrimethamine alone in Irian Jaya, Indonesia.单纯性恶性疟的治疗：在印度尼西亚伊里安查亚进行的一项随机试验，比较青蒿琥酯加磺胺多辛-乙胺嘧啶与单用磺胺多辛-乙胺嘧啶的疗效。
Am J Trop Med Hyg. 2001 Oct;65(4):309-17. doi: 10.4269/ajtmh.2001.65.309.
引用本文的文献
1
Seasonal malaria chemoprevention and mutations in and genes in children in the health district of Nanoro, Burkina Faso.布基纳法索纳诺罗健康区儿童的季节性疟疾化学预防以及**和**基因中的突变 （注：原文中“and”前后的内容缺失）
Malariaworld J. 2025 Mar 17;16:5. doi: 10.5281/zenodo.15039792. eCollection 2025.
2
Analysis of a diffusive two-strain malaria model with the carrying capacity of the environment for mosquitoes.具有蚊子环境容纳量的扩散两株疟疾模型分析
Infect Dis Model. 2024 May 11;9(3):931-962. doi: 10.1016/j.idm.2024.05.001. eCollection 2024 Sep.
3
Evaluation of Segmentation, Rotation, and Geographic Delivery Approaches for Deployment of Multiple First-Line Treatment (MFT) to Respond to Antimalarial Drug Resistance in Africa: A Qualitative Study in Seven Sub-Sahara Countries.评估在非洲部署多种一线治疗方案（MFT）以应对抗疟药物耐药性的分割、轮换和地理给药方法：在撒哈拉以南七个国家开展的定性研究
Trop Med Infect Dis. 2024 Apr 23;9(5):93. doi: 10.3390/tropicalmed9050093.
4
Assessing emergence risk of double-resistant and triple-resistant genotypes of Plasmodium falciparum.评估疟原虫双耐药和三耐药基因型的出现风险。
Nat Commun. 2024 Feb 15;15(1):1390. doi: 10.1038/s41467-024-45547-x.
5
Genetic Diversity and Resistance Genotype Profile in Infected Placental Samples Collected After Delivery in Ouagadougou.瓦加杜古分娩后采集的感染胎盘样本中的遗传多样性和抗性基因型概况
Infect Drug Resist. 2023 Oct 12;16:6673-6680. doi: 10.2147/IDR.S420004. eCollection 2023.
6
Molecular detection of drug-resistant mutants in Assam.在阿萨姆邦检测耐药突变体的分子方法。
Indian J Med Res. 2023 Jan;158(1):55-65. doi: 10.4103/ijmr.IJMR_2976_20.
7
Antiplasmodial Activity Evaluation of a Bestatin-Related Aminopeptidase Inhibitor, Phebestin.苯丁抑制肽类氨肽酶抑制剂 phebestin 的抗疟原虫活性评价
Antimicrob Agents Chemother. 2023 Jul 18;67(7):e0160622. doi: 10.1128/aac.01606-22. Epub 2023 Jun 14.
8
Amplicon Deep Sequencing Reveals Multiple Genetic Events Lead to Treatment Failure with Atovaquone-Proguanil in Plasmodium falciparum.扩增子深度测序揭示多种遗传事件导致恶性疟原虫阿托伐醌-磺胺多辛治疗失败。
Antimicrob Agents Chemother. 2023 Jun 15;67(6):e0170922. doi: 10.1128/aac.01709-22. Epub 2023 May 8.
9
Rational-Based Discovery of Novel β-Carboline Derivatives as Potential Antimalarials: From In Silico Identification of Novel Targets to Inhibition of Experimental Cerebral Malaria.基于理性设计发现新型β-咔啉衍生物作为潜在抗疟药：从新型靶点的计算机模拟鉴定到对实验性脑型疟疾的抑制
Pathogens. 2022 Dec 13;11(12):1529. doi: 10.3390/pathogens11121529.
10
Advances in Infectious Disease Vaccine Adjuvants.传染病疫苗佐剂的进展
Vaccines (Basel). 2022 Jul 13;10(7):1120. doi: 10.3390/vaccines10071120.
本文引用的文献
1
Malaria: living with drug resistance.疟疾：与耐药性共存。
Parasitol Today. 1993 May;9(5):168-74. doi: 10.1016/0169-4758(93)90140-b.
2
Did medicated salt hasten the spread of chloroquine resistance in Plasmodium falciparum?药用盐会加速恶性疟原虫对氯喹的抗药性传播吗？
Parasitol Today. 1988 Apr;4(4):112-5. doi: 10.1016/0169-4758(88)90042-7.
3
Impregnated fabrics against malaria mosquitoes.
Parasitol Today. 1985 Nov;1(5):147. doi: 10.1016/0169-4758(85)90063-8.
4
Current views on the population structure of plasmodium falciparum: Implications for control.当前对恶性疟原虫种群结构的看法：对疟疾控制的启示。
Parasitol Today. 1997 Jul;13(7):262-7. doi: 10.1016/s0169-4758(97)01075-2.
5
Population-based validation of dihydrofolate reductase gene mutations for the prediction of sulfadoxine-pyrimethamine resistance in Uganda.基于人群的二氢叶酸还原酶基因突变验证，用于预测乌干达的磺胺多辛-乙胺嘧啶耐药性。
Trans R Soc Trop Med Hyg. 2003 May-Jun;97(3):338-42. doi: 10.1016/s0035-9203(03)90163-5.
6
RESISTANCE OF MALARIA PARASITES TO DRUGS. REPORT OF A WHO SCIENTIFIC GROUP.
World Health Organ Tech Rep Ser. 1965;296:1-65.
7
Pitfalls in a discovery: the chronicle of chloroquine.一项发现中的陷阱：氯喹纪事
Am J Trop Med Hyg. 1963 Mar;12:121-8. doi: 10.4269/ajtmh.1963.12.121.
8
Observations on two Plasmodium falciparum infections with an abnormal response to chloroquine.关于两例对氯喹有异常反应的恶性疟原虫感染的观察
Am J Trop Med Hyg. 1961 Jan;10:5-9. doi: 10.4269/ajtmh.1961.10.5.
9
10
Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi.马拉维停用氯喹后氯喹敏感型恶性疟原虫疟疾再度出现。
J Infect Dis. 2003 Jun 15;187(12):1870-5. doi: 10.1086/375419. Epub 2003 May 21.
Zotero 插件