Török T, Bari F, Kardos A, Paprika D, Rudas L
Medical Intensive Care Unit, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Acta Physiol Hung. 1997;85(3):193-8.
The existence of an active vasodilator system in the human skin microvasculature is well documented, but its physiological role and the underlying mechanisms are not completely understood. Cutaneous blood flow increases during isometric handgrip exercise. To examine whether this response is mediated by active vasodilation, isometric handgrip exercise testing was performed in nine healthy subjects. Local iontophoresis of atropine was applied to the forearm skin. Skin blood flow (SBF) monitoring by means of laser Doppler flowmetry was combined with continuous noninvasive blood pressure monitoring. SBF monitoring was performed at a site pretreated with atropine and an adjacent control area. Mean arterial pressure (MAP) was recorded noninvasively. Cutaneous vascular resistance (CVR) was calculated as MAP/SBF for the atropine treated and the control areas. Changes in CVR were expressed as percent deviation from the baseline (dCVR). Isometric handgrip exercise resulted in a marked reduction in CVR at the control site (dCVR: -66 +/- 4%). In contrast, the CVR was not significantly altered at the atropinetreated site (2.4 +/- 7%). It is concluded that isometric exercise induces an atropine-sensitive vasodilation which is mediated by muscarinic receptors in the human skin.
人体皮肤微血管系统中存在活性血管舒张系统，这一点已有充分的文献记载，但其生理作用及潜在机制尚未完全明确。等长握力运动时皮肤血流量会增加。为了研究这种反应是否由活性血管舒张介导，对9名健康受试者进行了等长握力运动测试。将阿托品局部离子导入前臂皮肤。通过激光多普勒血流仪监测皮肤血流量（SBF），并结合连续无创血压监测。在经阿托品预处理的部位和相邻的对照区域进行SBF监测。无创记录平均动脉压（MAP）。计算阿托品处理区域和对照区域的皮肤血管阻力（CVR），公式为MAP/SBF。CVR的变化以相对于基线的百分比偏差（dCVR）表示。等长握力运动导致对照部位的CVR显著降低（dCVR：-66±4%）。相比之下，经阿托品处理部位的CVR没有明显改变（2.4±7%）。得出的结论是，等长运动可诱导由人体皮肤中的毒蕈碱受体介导的对阿托品敏感的血管舒张。
