Scolding N J, Franklin R J
MRC Cambridge Centre for Brain Repair, University of Cambridge, UK.
Baillieres Clin Neurol. 1997 Oct;6(3):525-48.
In multiple sclerosis, partial remyelination is conspicuous in many lesions, and is thought to contribute significantly to lasting recovery from acute relapse. However, myelin repair ultimately fails during progression of the disease, as disability and handicap accumulate. In this chapter we explore the biological background to myelin repair in CNS demyelinating disease, and the reasons underlying the failure of more widespread and lasting remyelination in multiple sclerosis. Experimental studies provide clear evidence that therapies promoting myelin repair can be highly successful in the CNS, and we discuss the clinical approaches which might allow the translation of these laboratory studies to neurological practice, together with some of the potential hazards and pitfalls likely to arise.
在多发性硬化症中，许多病灶中明显存在部分髓鞘再生现象，且被认为对急性复发后的持久恢复有显著贡献。然而，在疾病进展过程中，随着残疾和功能障碍的累积，髓鞘修复最终会失败。在本章中，我们探讨了中枢神经系统脱髓鞘疾病中髓鞘修复的生物学背景，以及多发性硬化症中更广泛、持久的髓鞘再生失败的潜在原因。实验研究提供了明确证据，表明促进髓鞘修复的疗法在中枢神经系统中可能非常成功，我们还讨论了有可能将这些实验室研究转化为神经科临床实践的临床方法，以及可能出现的一些潜在风险和陷阱。
