Franklin Robin J M
Department of Clinical Veterinary Medicine and Cambridge Centre for Brain Repair, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK.
Nat Rev Neurosci. 2002 Sep;3(9):705-14. doi: 10.1038/nrn917.
Multiple sclerosis is a common cause of neurological disability in young adults. The disease is complex -- its aetiology is multifactorial and largely unknown; its pathology is heterogeneous; and, clinically, it is difficult to diagnose, manage and treat. However, perhaps its most frustrating aspect is the inadequacy of the healing response of remyelination. This regenerative process generally occurs with great efficiency in experimental models, and sometimes proceeds to completion in multiple sclerosis. But as the disease progresses, the numbers of lesions in which demyelination persists increases, significantly contributing to clinical deterioration. Understanding why remyelination fails is crucial for devising effective methods by which to enhance it.
多发性硬化症是年轻成年人神经功能障碍的常见病因。该疾病很复杂——其病因是多因素的，且在很大程度上尚不明确；其病理具有异质性；而且在临床上，诊断、管理和治疗都很困难。然而，或许其最令人沮丧的方面是髓鞘再生修复反应的不足。在实验模型中，这个再生过程通常高效发生，在多发性硬化症中有时也能完成。但随着疾病进展，脱髓鞘持续存在的病灶数量增加，这对临床恶化有显著影响。了解髓鞘再生失败的原因对于设计有效增强其再生的方法至关重要。
