Fesani F, Barboso G, Rolli A, Medici D, Campodonoco R, Busi M, Corsi M, Caldarera C M
G Ital Cardiol. 1976;6(2):225-31.
An experimental study on myocardial viability after acute occlusion of the left anterior descending coronary artery (LAD) for period of six hours is described. For this study 24 adult dogs were used in which an acute myocardial infarction for an area of 20-30% of left ventricul were obtained with ligatures completely occluding the LAD and his collaterals. Following ligature release, on the LAD only, ECG, BP, VCP and histology were studied with the general clinical conditions. The Authors affirm that clinical and ECGraphic data became worse after reperfusion; instead histological data show the possibility of recovery of many muscolar cells of ischemic and neighbouring areas.
本文描述了一项关于左前降支冠状动脉(LAD)急性闭塞6小时后心肌活力的实验研究。在该研究中,使用了24只成年犬,通过完全结扎LAD及其侧支,造成左心室20%-30%面积的急性心肌梗死。结扎解除后,仅对LAD进行研究,同时观察心电图(ECG)、血压(BP)、心室造影(VCP)以及组织学情况,并综合分析一般临床状况。作者断言,再灌注后临床和心电图数据恶化;相反,组织学数据显示缺血区域及相邻区域的许多肌细胞有可能恢复。