Shingleton W B, Terrell F, Renfroe L, Kolski J, Fowler J E
Division of Urology, University of Mississippi Medical Center, Jackson 39216, USA.
J Endourol. 1999 Feb;13(1):49-52. doi: 10.1089/end.1999.13.49.
Current treatment technique for laser prostatectomy involve Nd:YAG wavelength at 60 to 80 W. Use of the KTP wavelength in addition to Nd:YAG allows for vaporization of more tissue, decreasing the amount undergoing coagulation necrosis. In this study, we compared 20 W and 40 W of KTP laser energy in conjunction with the Nd:YAG wavelength for the treatment of benign prostatic hyperplasia (BPH).
A total of 50 consecutive patients underwent laser ablation of the prostate, with 38 patients (Group I) receiving treatment with 20 W of the KTP and 60 W of the Nd:YAG wavelengths. The other 12 patients (Group II) underwent treatment with 40 W of KTP and 60 W of Nd:YAG laser energy. The patients had an initial evaluation consisting of American Urological Association (AUA) Symptom Score, uroflowmetry, transrectal ultrasonography for prostate volume measurement, and assay of prostate specific antigen (PSA) serum level. The patients were seen in follow-up at 1, 3, and 6 months.
The mean symptom score decreased from 23.4 to 8.9 from Group I and from 18.2 to 3.5 for Group II at the 6-month follow-up. The mean peak urinary flow rate increased from 8.4 to 15.4 mL/sec Group I and from 8.3 to 16.5 mL/sec in Group II at the 6-month follow-up.
The patients treated with the 40 W of KTP laser energy experienced a more rapid and sustained improvement in symptom score than those treated at 20 W. The improvement in peak urinary flow rate was approximately the same in the two groups.
目前激光前列腺切除术的治疗技术采用波长为60至80瓦的钕钇铝石榴石(Nd:YAG)激光。除Nd:YAG激光外,使用磷酸钛氧钾(KTP)波长可汽化更多组织,减少发生凝固性坏死的组织量。在本研究中,我们比较了20瓦和40瓦KTP激光能量联合Nd:YAG波长治疗良性前列腺增生(BPH)的效果。
共有50例连续患者接受了前列腺激光消融治疗,其中38例患者(I组)接受20瓦KTP和60瓦Nd:YAG波长的治疗。另外12例患者(II组)接受40瓦KTP和60瓦Nd:YAG激光能量的治疗。患者最初的评估包括美国泌尿外科学会(AUA)症状评分、尿流率测定、经直肠超声检查测量前列腺体积以及检测前列腺特异性抗原(PSA)血清水平。患者在1个月、3个月和6个月时进行随访。
在6个月的随访中,I组的平均症状评分从23.4降至8.9,II组从18.2降至3.5。在6个月的随访中,I组的平均最大尿流率从8.4毫升/秒增至15.4毫升/秒,II组从8.3毫升/秒增至16.5毫升/秒。
接受40瓦KTP激光能量治疗的患者在症状评分方面比接受20瓦治疗的患者改善得更快且更持久。两组的最大尿流率改善情况大致相同。