Hansson T, Lidman U
Acta Pharmacol Toxicol (Copenh). 1978 Jul;43(1):6-12. doi: 10.1111/j.1600-0773.1978.tb02225.x.
The effects of cortisol on components of the liver microsomal mixed function oxidase system (MFO) of immature and starved rainbow trout, Salmo gairdnerii, Rich., were studied 3, 7 and 21 days after intraperitoneal implantation of cortisol-containing cholesterol pellets. The treatment resulted in significantly elevated NADPH cytochrome c reductase activities, concomitant with elevated plasma cortisol levels, at all sampling events, while no significant effects on either liver cytochrome P-450 or microsomal protein contents was observed. The cortisol-treated fish lost considerably more body weight than corresponding controls during the experimental period, while the effects on liver wet weight and liver somatic index were inconclusive.
研究了腹腔植入含皮质醇的胆固醇丸剂3、7和21天后，皮质醇对未成熟和饥饿的虹鳟（Salmo gairdnerii, Rich.）肝脏微粒体混合功能氧化酶系统（MFO）各组分的影响。在所有采样时间点，该处理均导致NADPH细胞色素c还原酶活性显著升高，同时血浆皮质醇水平也升高，而未观察到对肝脏细胞色素P - 450或微粒体蛋白含量有显著影响。在实验期间，经皮质醇处理的鱼比相应的对照组体重减轻得多，而对肝脏湿重和肝脏体指数的影响尚无定论。
