日粮环丙烯脂肪酸对虹鳟（萨氏虹鳟）混合功能氧化酶系统的影响。
Effects of dietary cyclopropene fatty acids on the mixed function oxidase system of the rainbow trout (Salmo gairdneri).
作者信息
Eisele T A, Nixon J E, Pawlowski N E, Sinnhuber R O
出版信息
J Environ Pathol Toxicol. 1978 Jul-Aug;1(6):773-8.
Dietary cyclopropene fatty acids (CPFA) in rainbow trout (Salmo gairdneri) decreased cytochrome P-450 and b5 content and NADPH-cytochrome c reductase activity 67.8 percent, 22.0 percent, and 38.4 percent respectively compared to control-fed trout after 22 days. Dietary CPFA induced benzo(alpha)pyrene aryl hydrocarbon hydroxylase 37.5 percent over controls for the same time period. Microsomal protein levels were consistently lower in CPFA-fed trout. This pattern remained established in CPFA-fed trout for the duration of the experiment (74 days). The data suggest a possible mechanism by which dietary CPFA act as co-carcinogens.
虹鳟鱼（萨氏虹鳟）日粮中的环丙烯脂肪酸（CPFA），与对照日粮喂养的虹鳟鱼相比，22天后细胞色素P - 450和b5含量以及NADPH - 细胞色素c还原酶活性分别降低了67.8%、22.0%和38.4%。在同一时期，日粮CPFA使苯并（α）芘芳烃羟化酶比对照高出37.5%。喂食CPFA的虹鳟鱼微粒体蛋白水平始终较低。在整个实验期间（74天），这种模式在喂食CPFA的虹鳟鱼中一直存在。数据表明日粮CPFA作为辅助致癌物起作用的一种可能机制。
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