Weber F, Janovskaja J, Polak T, Poser S, Rieckmann P
Department of Neurology, Georg-August-University of Göttingen, Germany.
Neurology. 1999 Mar 23;52(5):1069-71. doi: 10.1212/wnl.52.5.1069.
The effect of interferon (IFN)beta-1a and IFNbeta-1b on human myelin basic protein-reactive T-cell lines was investigated. Both drugs inhibited proliferation and production of lymphotoxin (LT), whereas the production of interleukin-4 was not altered and interleukin-10 was induced. Comparing equal numbers of units IFNbeta-1a and -1b showed almost identical results. These in vitro data indicate that the immunomodulatory capacity of both interferons with respect to T cells paralleled their antiviral effect.
研究了干扰素（IFN）β-1a和IFNβ-1b对人髓鞘碱性蛋白反应性T细胞系的影响。两种药物均抑制淋巴细胞毒素（LT）的增殖和产生，而白细胞介素-4的产生未改变，且诱导了白细胞介素-10的产生。比较等量单位的IFNβ-1a和-1b显示出几乎相同的结果。这些体外数据表明，两种干扰素对T细胞的免疫调节能力与其抗病毒作用相似。
