Kim H J, Cho M Y, Park Y N, Kie J H
Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
J Korean Med Sci. 1999 Feb;14(1):57-62. doi: 10.3346/jkms.1999.14.1.57.
Primary testicular carcinoid tumor, occupying 0.23% of testicular neoplasm, is a rare and indolent neoplasm with the potential for distant metastasis. We present two cases of primary pure carcinoid tumor of the testis. Both patients were 36 years old. Physical examination revealed testicular mass with and without tenderness. The preoperative serum levels of beta-human chorionic gonadotropin and alpha-fetoprotein were normal and neither patient had carcinoid syndrome. The tumors measured 7.5x6x4 cm and 5.5x5x4 cm in size. Histologically, immunohistochemically and ultrastructurally, the tumors showed typical features of the carcinoid tumor. Case 1 showed extensive tumor necrosis and vascular invasion. DNA flow cytometric analysis showed aneuploidy with DNA index of 1.47 and S+G2M of 14.0% in case 1 and tetraploidy with DNA index of 1.96 and S+G2M of 22.1% in case 2. Both patients have been well without any signs of metastasis after operation for 24 months in case 1 and for 16 months in case 2.
原发性睾丸类癌肿瘤占睾丸肿瘤的0.23%，是一种罕见的惰性肿瘤，有远处转移的可能。我们报告两例原发性睾丸纯类癌肿瘤病例。两名患者均为36岁。体格检查发现睾丸肿块，有或无压痛。术前血清β-人绒毛膜促性腺激素和甲胎蛋白水平正常，两名患者均无类癌综合征。肿瘤大小分别为7.5×6×4 cm和5.5×5×4 cm。在组织学、免疫组织化学和超微结构上，肿瘤表现出类癌肿瘤的典型特征。病例1显示广泛的肿瘤坏死和血管侵犯。DNA流式细胞术分析显示，病例1为非整倍体，DNA指数为1.47，S+G2M为14.0%；病例2为四倍体，DNA指数为1.96，S+G2M为22.1%。病例1术后24个月、病例2术后16个月，两名患者均情况良好，无任何转移迹象。
