Cho Y J, Han D S, Kim T Y, Jang S J, Jeon Y C, Sohn J H, Lee I H, Park K N
Department of Internal Medicine, Hanyang University, College of Medicine, Seoul, Korea.
J Korean Med Sci. 1999 Feb;14(1):102-6. doi: 10.3346/jkms.1999.14.1.102.
Autoimmune cholangitis is a clinical constellation of chronic cholestasis, histological changes of chronic nonsuppurative cholangitis and the presence of autoantibodies other than antimitochondrial antibody (AMA). It is uncertain whether this entity is definitely different from AMA positive primary biliary cirrhosis (PBC), though it shows some differences. We report a case of autoimmune cholangitis in a 59-year-old woman, who had been previously diagnosed as AMA-positive PBC associated with rheumatoid arthritis, has been converted to an AMA-negative and anticentromere antibody-positive PBC during follow-up. The response to ursodeoxycholic acid treatment is poor except within the first few months, but prednisolone was dropping the biochemical laboratory data.
自身免疫性胆管炎是一种临床综合征，表现为慢性胆汁淤积、慢性非化脓性胆管炎的组织学改变以及除抗线粒体抗体（AMA）以外的自身抗体的存在。尽管自身免疫性胆管炎与AMA阳性的原发性胆汁性肝硬化（PBC）存在一些差异，但该实体是否与AMA阳性的原发性胆汁性肝硬化（PBC）绝对不同尚不确定。我们报告一例59岁女性自身免疫性胆管炎病例，该患者先前被诊断为与类风湿关节炎相关的AMA阳性PBC，在随访期间转变为AMA阴性且抗着丝点抗体阳性的PBC。除最初几个月外，熊去氧胆酸治疗反应不佳，但泼尼松龙可降低生化实验室数据。
