Renshaw P F, Daniels S, Lundahl L H, Rogers V, Lukas S E
Brain Imaging Center, McLean Hospital/Harvard Medical School, Belmont, MA 02478, USA.
Psychopharmacology (Berl). 1999 Feb;142(2):132-8. doi: 10.1007/s002130050871.
The administration of cytidine-5'-diphosphate choline (CDP-choline, citicoline) to animals increases the rate of membrane phospholipid synthesis and elevates brain dopamine levels. Because cocaine dependence has been associated with increases in brain phospholipid precursors, as well as depletion of dopamine within the central nervous system, the present outpatient study was conducted to assess the safety of citicoline (500 mg bid) and to determine if short-term treatment alters mood states and cocaine craving in subjects with a history of cocaine dependence. In addition, measures of drug craving and mood states after presentation of cocaine-related cues were collected on two occasions: before and after 14 days of double-blind treatment with either citicoline or placebo. Subjects did not experience any side effects and citicoline treatment was associated with decreases in self-reported mood states associated with cocaine craving. These preliminary data are encouraging and suggest that citicoline warrants further study as a promising potential treatment for cocaine abuse and dependence that is devoid of side effects.
给动物施用胞苷-5'-二磷酸胆碱（CDP-胆碱，西地胆碱）可提高膜磷脂合成速率并提高脑内多巴胺水平。由于可卡因成瘾与脑磷脂前体增加以及中枢神经系统内多巴胺耗竭有关，因此开展了本门诊研究，以评估西地胆碱（500毫克，每日两次）的安全性，并确定短期治疗是否会改变有可卡因成瘾史受试者的情绪状态和对可卡因的渴望。此外，在两次情况下收集了呈现可卡因相关线索后对药物渴望和情绪状态的测量数据：在接受西地胆碱或安慰剂双盲治疗14天之前和之后。受试者未出现任何副作用，西地胆碱治疗与与可卡因渴望相关的自我报告情绪状态下降有关。这些初步数据令人鼓舞，并表明西地胆碱作为一种有前景的、无副作用的可卡因滥用和成瘾潜在治疗方法值得进一步研究。
