Spiers P A, Myers D, Hochanadel G S, Lieberman H R, Wurtman R J
Clinical Research Center, Massachusetts Institute of Technology, Cambridge, USA.
Arch Neurol. 1996 May;53(5):441-8. doi: 10.1001/archneur.1996.00550050071026.
To test the verbal memory of older volunteers given citicoline.
A randomized, double-blind, placebo-controlled, parallel group design was employed in the initial study. After data analysis, a subgroup was identified whose members had relatively inefficient memories. These subjects were recruited for a second study that used a crossover design. The subjects took either placebo or citicoline, 1000 mg/d, for 3 months in the initial study. In the crossover study, subjects took both placebo and citicoline, 2000 mg/d, each for 2 months.
The subjects were 47 female and 48 male volunteers 50 to 85 years old. They were screened for dementia, memory disorders, and other neurological problems. Of the subjects with relatively inefficient memories, 32 participated in the crossover study.
Verbal memory was tested at each study visit using a logical memory passage. Plasma choline concentrations were measured at baseline; at days 30, 60, and 90 in the initial study; and at day 60 of each treatment condition in the crossover study. Plasma choline concentrations and memory scores were analyzed using repeated-measures analysis of variance and covariance, followed by planned comparisons when appropriate.
In the initial study, citicoline therapy improved delayed recall on logical memory only for the subjects with relatively inefficient memories. In the crossover study, the higher dosage of citicoline was clearly associated with improved immediate and delayed logical memory.
Citicoline therapy improved verbal memory functioning in older individuals with relatively inefficient memories. Citicoline may prove effective in treating age-related cognitive decline that may be the precursor of dementia.
测试服用胞磷胆碱的老年志愿者的言语记忆。
初始研究采用随机、双盲、安慰剂对照、平行组设计。数据分析后，确定了一个记忆效率相对较低的亚组。这些受试者被招募参加第二项采用交叉设计的研究。在初始研究中，受试者服用安慰剂或1000毫克/天的胞磷胆碱，为期3个月。在交叉研究中，受试者分别服用安慰剂和2000毫克/天的胞磷胆碱，各为期2个月。
受试者为47名女性和48名男性志愿者，年龄在50至85岁之间。他们接受了痴呆、记忆障碍和其他神经问题的筛查。在记忆效率相对较低的受试者中，有32人参加了交叉研究。
每次研究访视时使用逻辑记忆段落测试言语记忆。在基线时、初始研究的第30、60和90天以及交叉研究中每种治疗条件的第60天测量血浆胆碱浓度。使用重复测量方差分析和协方差分析血浆胆碱浓度和记忆分数，然后在适当的时候进行计划比较。
在初始研究中，胞磷胆碱治疗仅改善了记忆效率相对较低的受试者在逻辑记忆上的延迟回忆。在交叉研究中，较高剂量的胞磷胆碱与即时和延迟逻辑记忆的改善明显相关。
胞磷胆碱治疗改善了记忆效率相对较低的老年人的言语记忆功能。胞磷胆碱可能被证明对治疗可能是痴呆症前兆的与年龄相关的认知衰退有效。
