Timmermans M C, Hudson A, Becraft P W, Nelson T
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA.
Science. 1999 Apr 2;284(5411):151-3. doi: 10.1126/science.284.5411.151.
The regulation of members of the knotted1-like homeobox (knox) gene family is required for the normal initiation and development of lateral organs. The maize rough sheath2 (rs2) gene, which encodes a Myb-domain protein, is expressed in lateral organ primordia and their initials. Mutations in the rs2 gene permit ectopic expression of knox genes in leaf and floral primordia, causing a variety of developmental defects. Ectopic KNOX protein accumulation in rs2 mutants occurs in a subset of the normal rs2-expressing cells. This variegated accumulation of KNOX proteins in rs2 mutants suggests that rs2 represses knox expression through epigenetic means.
类knotted1同源异型框（knox）基因家族成员的调控对于侧生器官的正常起始和发育是必需的。玉米粗糙叶鞘2（rs2）基因编码一种Myb结构域蛋白，在侧生器官原基及其起始部位表达。rs2基因突变会使knox基因在叶和花原基中异位表达，导致多种发育缺陷。rs2突变体中异位的KNOX蛋白积累发生在正常表达rs2的部分细胞中。rs2突变体中KNOX蛋白的这种斑驳积累表明rs2通过表观遗传方式抑制knox表达。
