鼠伤寒沙门氏菌DT104抗生素抗性基因簇的分子特征分析
Molecular characterization of an antibiotic resistance gene cluster of Salmonella typhimurium DT104.
作者信息
Briggs C E, Fratamico P M
机构信息
Agricultural Research Service, U.S. Department of Agriculture, Wyndmoor, Pennsylvania 19038, USA.
出版信息
Antimicrob Agents Chemother. 1999 Apr;43(4):846-9. doi: 10.1128/AAC.43.4.846.
Abstract
Salmonella typhimurium phage type DT104 has become an important emerging pathogen. Isolates of this phage type often possess resistance to ampicillin, chloramphenicol, streptomycin, sulfonamides, and tetracycline (ACSSuT resistance). The mechanism by which DT104 has accumulated resistance genes is of interest, since these genes interfere with treatment of DT104 infections and might be horizontally transferred to other bacteria, even to unrelated organisms. Previously, several laboratories have shown that the antibiotic resistance genes of DT104 are chromosomally encoded and involve integrons. The antibiotic resistance genes conferring the ACSSuT-resistant phenotype have been cloned and sequenced. These genes are grouped within two district integrons and intervening plasmid-derived sequences. This sequence is potentially useful for detection of multiresistant DT104.
摘要
鼠伤寒沙门氏菌DT104噬菌体类型已成为一种重要的新出现病原体。这种噬菌体类型的分离株通常对氨苄青霉素、氯霉素、链霉素、磺胺类药物和四环素具有抗性（ACSSuT抗性）。DT104积累抗性基因的机制备受关注，因为这些基因会干扰DT104感染的治疗，并且可能水平转移至其他细菌，甚至是不相关的生物体。此前，多个实验室已表明DT104的抗生素抗性基因是由染色体编码的，且涉及整合子。赋予ACSSuT抗性表型的抗生素抗性基因已被克隆和测序。这些基因被归为两个不同的整合子以及其间的质粒衍生序列。该序列对于检测多重耐药的DT104可能有用。
相似文献
1
Molecular characterization of an antibiotic resistance gene cluster of Salmonella typhimurium DT104.
Antimicrob Agents Chemother. 1999 Apr;43(4):846-9. doi: 10.1128/AAC.43.4.846.
2
[Molecular characterization of Salmonella enterica serovar Typhimurium strains isolated from humans in Turkey].
Mikrobiyol Bul. 2015 Oct;49(4):502-12. doi: 10.5578/mb.9940.
3
Analysis of integrons in human isolates of Salmonella enterica serovar typhimurium isolated in the Slovak Republic.
FEMS Microbiol Lett. 2004 Oct 1;239(1):25-31. doi: 10.1016/j.femsle.2004.08.013.
4
Multidrug-resistant Salmonella typhimurium and Salmonella enteritidis identified by multiplex PCR from animals.
J Vet Sci. 2001 Dec;2(3):181-8.
5
Detection of multidrug-resistant Salmonella enterica serovar typhimurium phage types DT102, DT104, and U302 by multiplex PCR.
J Clin Microbiol. 2006 Jul;44(7):2354-8. doi: 10.1128/JCM.00171-06.
6
Characterization of resistance genes in multidrug-resistant Salmonella enterica serotype Typhimurium isolated from diseased cattle in France (2002 to 2007).
Foodborne Pathog Dis. 2010 Apr;7(4):419-25. doi: 10.1089/fpd.2009.0414.
7
Variation in clonality and antibiotic-resistance genes among multiresistant Salmonella enterica serotype typhimurium phage-type U302 (MR U302) from humans, animals, and foods.
Microb Drug Resist. 2001 Spring;7(1):13-21. doi: 10.1089/107662901750152701.
8
Multidrug-resistant Salmonella Typhimurium DT104 in poultry.
J Food Prot. 2000 Feb;63(2):155-61. doi: 10.4315/0362-028x-63.2.155.
9
Detection of multidrug-resistant Salmonella typhimurium DT104 by multiplex polymerase chain reaction.
FEMS Microbiol Lett. 2000 Jan 15;182(2):355-60. doi: 10.1111/j.1574-6968.2000.tb08921.x.
10
Epidemiology and characterization of animal Salmonella enterica subspecies Enterica serotype typhimurium DT104 in Hungary.
Acta Vet Hung. 2000;48(4):407-20.
引用本文的文献
1
Trends in horizontal gene transfer research in antimicrobial resistance: a bibliometric analysis.
Front Microbiol. 2024 Sep 12;15:1439664. doi: 10.3389/fmicb.2024.1439664. eCollection 2024.
2
Maribacter halichondriae sp. nov., isolated from the marine sponge Halichondria panicea, displays features of a sponge-associated life style.
Antonie Van Leeuwenhoek. 2024 Mar 15;117(1):56. doi: 10.1007/s10482-024-01950-4.
3
Salmonella serovars trend in poultry Malaysia from 2011 to 2020.
Vet Res Commun. 2024 Jun;48(3):1791-1802. doi: 10.1007/s11259-024-10303-5. Epub 2024 Jan 19.
4
Antimicrobial resistance and virulence genes of invasive from children with bacteremia in north-central Nigeria.
SAGE Open Med. 2023 May 20;11:20503121231175322. doi: 10.1177/20503121231175322. eCollection 2023.
5
Antibiotic-Resistant Bacteria in Aquaculture and Climate Change: A Challenge for Health in the Mediterranean Area.
Int J Environ Res Public Health. 2021 May 26;18(11):5723. doi: 10.3390/ijerph18115723.
6
Genomic Characterization of DT104 Strains Associated with Cattle and Beef Products.
Pathogens. 2021 Apr 27;10(5):529. doi: 10.3390/pathogens10050529.
7
Natural Occurrence of -Infecting Bacteriophages in Clinical Samples.
Front Microbiol. 2019 Oct 31;10:2484. doi: 10.3389/fmicb.2019.02484. eCollection 2019.
8
Characterization of Bacteria and Inducible Phages in an Intensive Care Unit.
J Clin Med. 2019 Sep 10;8(9):1433. doi: 10.3390/jcm8091433.
9
The Effect of Previous Life Cycle Phase on the Growth Kinetics, Morphology, and Antibiotic Resistance of Typhimurium DT104 in Brain Heart Infusion and Ground Chicken Extract.
Front Microbiol. 2019 May 24;10:1043. doi: 10.3389/fmicb.2019.01043. eCollection 2019.
10
The resistomes of six carbapenem-resistant pathogens - a critical genotype-phenotype analysis.
Microb Genom. 2018 Nov;4(11). doi: 10.1099/mgen.0.000233. Epub 2018 Nov 21.
本文引用的文献
1
Emergence of multidrug-resistant Salmonella enterica serotype typhimurium DT104 infections in the United States.
N Engl J Med. 1998 May 7;338(19):1333-8. doi: 10.1056/NEJM199805073381901.
2
New hunt for the roots of resistance.
Science. 1998 Apr 3;280(5360):27. doi: 10.1126/science.280.5360.27.
3
Containment of antibiotic resistance.
Science. 1998 Feb 20;279(5354):1153-4. doi: 10.1126/science.279.5354.1153.
4
Characterisation of integrons and antibiotic resistance genes in Danish multiresistant Salmonella enterica Typhimurium DT104.
FEMS Microbiol Lett. 1998 Mar 1;160(1):37-41. doi: 10.1111/j.1574-6968.1998.tb12887.x.
5
Antimicrobial resistance of Salmonella enterica typhimurium DT104 isolates and investigation of strains with transferable apramycin resistance.
Epidemiol Infect. 1997 Apr;118(2):97-103. doi: 10.1017/s0950268896007339.
6
Pathogenicity islands and the evolution of bacterial pathogens.
Infect Agents Dis. 1996 Jan;5(1):1-7.
7
Isolation and structure of a new integron that includes a streptomycin resistance gene from the R plasmid of Pseudomonas aeruginosa.
FEMS Microbiol Lett. 1995 Dec 15;134(2-3):137-41. doi: 10.1111/j.1574-6968.1995.tb07927.x.
8
Gene cassettes: a new class of mobile element.
Microbiology (Reading). 1995 Dec;141 ( Pt 12):3015-27. doi: 10.1099/13500872-141-12-3015.
9
Epidemic in cattle and humans of Salmonella typhimurium DT 104 with chromosomally integrated multiple drug resistance.
Vet Rec. 1994 May 28;134(22):577. doi: 10.1136/vr.134.22.577.
10
Transmission of multi-resistant strains of Salmonella typhimurium from cattle to man.
Vet Rec. 1995 Jun 10;136(23):591-2. doi: 10.1136/vr.136.23.591.
Zotero 插件