Sandvang D, Aarestrup F M, Jensen L B
Danish Veterinary Laboratory, Copenhagen, Denmark.
FEMS Microbiol Lett. 1998 Mar 1;160(1):37-41. doi: 10.1111/j.1574-6968.1998.tb12887.x.
The presence and genetic content of integrons was investigated in eight Salmonella enteritica Typhimurium DT104 isolates from different pig herds in Denmark. Two different integrons were identified using PCR and sequencing. Each of the integrons carried a single resistance cassette in addition to the sull and qacE delta 1 genes characteristic of integrons. The first integron encoded the ant (3")-1a gene that specified resistance to spectinomycin and streptomycin. The second contained the pse-1 beta-lactamase gene. All the multiresistant strains contained both integrons. The presence of these two integrons did not account for the total phenotypic resistance of all the isolates and does not exclude the presence of other mobile DNA elements.
对来自丹麦不同猪群的8株肠炎沙门氏菌鼠伤寒血清型DT104分离株中的整合子存在情况及其基因内容进行了研究。通过PCR和测序鉴定出两种不同的整合子。除整合子特有的sull和qacEΔ1基因外，每个整合子还携带一个单一抗性盒。第一个整合子编码对壮观霉素和链霉素具有抗性的ant(3")-1a基因。第二个整合子包含pse-1β-内酰胺酶基因。所有多重耐药菌株都含有这两种整合子。这两种整合子的存在并不能解释所有分离株的全部表型抗性，也不排除其他可移动DNA元件的存在。
