Wyand M S, Manson K H, Miller C J, Neurath A R
Primedica Corporation, Worcester, Massachusetts 01608, USA.
Antimicrob Agents Chemother. 1999 Apr;43(4):978-80. doi: 10.1128/AAC.43.4.978.
Heterosexual transmission of human immunodeficiency virus type 1 (HIV-1) is the major cause of the ongoing AIDS epidemic. Application of chemical barrier methods is expected to contribute to the worldwide control of this epidemic. Bovine beta-lactoglobulin modified by 3-hydroxyphthalic anhydride (3-hydroxyphthalovyl-beta-lactoglobulin [3HP-beta-LG]) was shown to inhibit HIV-1, HIV-2, simian immunodeficiency virus (SIV), herpes simplex virus type 1 and 2, and Chlamydia trachomatis infection in vitro. Here, we show that 3HP-beta-LG not formulated into any vehicle protected three of six rhesus monkeys against vaginal infection by SIV. Incorporation of the compound into an appropriate vehicle is expected to increase the degree of protection. 3HP-beta-LG may be effective as a vaginal inhibitor of HIV-1 infection in humans.
1型人类免疫缺陷病毒（HIV-1）的异性传播是当前艾滋病流行的主要原因。应用化学屏障方法有望有助于在全球范围内控制这一流行病。经3-羟基邻苯二甲酸酐修饰的牛β-乳球蛋白（3-羟基邻苯二甲酰-β-乳球蛋白[3HP-β-LG]）在体外显示出可抑制HIV-1、HIV-2、猴免疫缺陷病毒（SIV）、1型和2型单纯疱疹病毒以及沙眼衣原体感染。在此，我们表明未制成任何载体的3HP-β-LG保护了六只恒河猴中的三只免受SIV的阴道感染。将该化合物掺入合适的载体有望提高保护程度。3HP-β-LG可能作为人类HIV-1感染的阴道抑制剂有效。
