Agarwala G C, Mittal R K, Bapat S K, Bharadwaj U R
Indian J Physiol Pharmacol. 1976 Oct-Dec;20(4):209-15.
The effect of minimal doses of glucagon, administered by intracerebroventricular (ICV) and intracisternal(IC) routes, on urine output in mongrel dogs have been studied. The dose of 2.0 mug of glucagon was found to be the minimal dose for diuresis on peripheral administration. This dose when centrally administered, produced an oliguric effect in animals. This effect was not observed in vagosympathectomised-spinal cord transectomised or adrenalectomised animals. It is suggested that the probable efferents might be the sympathetic fibres as they are present in vagi nerves as well in the spinal cord (26). The observations made in an attempt to find out the organ responsible for the oliguric effect, showed that some substance released from the adrenal cortex has an influence on the kidney's excretory function.
已经研究了通过脑室内（ICV）和脑池内（IC）途径给予最小剂量胰高血糖素对杂种犬尿量的影响。发现外周给药时，2.0微克胰高血糖素的剂量是产生利尿作用的最小剂量。当该剂量经中枢给药时，在动物中产生少尿作用。在迷走神经交感神经切断术-脊髓横断术或肾上腺切除术的动物中未观察到这种作用。提示可能的传出神经可能是交感神经纤维，因为它们存在于迷走神经和脊髓中（26）。为找出导致少尿作用的器官而进行的观察表明，肾上腺皮质释放的某些物质对肾脏的排泄功能有影响。
