Agarwala G C, Bapat S K
Indian J Physiol Pharmacol. 1977 Apr-Jun;21(2):99-106.
The effects of insulin administration via intracerebroventricular (ICV), third ventricular (TV) and intracisternal (IC) routes on the urine output and sodium excretion have been studied in mongrel dogs. The central administration of insulin resulted in a significant increase in urine output and sodium excretion. This diuresis and natriuresis was not observed in animals which had undergone either spinal-cord transectomy or adrenalectomy. The insulin-sensitive receptors for this diuresis and natriuresis seem to be present in the vicinity of the fourth-ventricle of the brain. The observations in the present study suggest that the probable efferents might be the sympathetic fibers in the spinal-cord. The centrally administered insulin inhibits the secretion of some substance from the adrenal cortex, which in turn results in the diuresis and natriuresis in animals.
通过脑室内（ICV）、第三脑室（TV）和脑池内（IC）途径给予胰岛素对杂种犬尿量和钠排泄的影响已得到研究。中枢给予胰岛素导致尿量和钠排泄显著增加。在接受脊髓横断术或肾上腺切除术的动物中未观察到这种利尿和利钠作用。这种利尿和利钠作用的胰岛素敏感受体似乎存在于脑第四脑室附近。本研究中的观察结果表明，可能的传出神经可能是脊髓中的交感神经纤维。中枢给予的胰岛素抑制肾上腺皮质某些物质的分泌，进而导致动物出现利尿和利钠作用。
