St John R K
J Am Vener Dis Assoc. 1976 Dec;3(2 Pt 2):148-52.
The English literature on the treatment of cardiovascular syphilis with penicillin was reviewed. To date there have been no controlled randomized clinical trials to demonstrate that penicillin therapy prolongs life expectancy, alleviates symptoms, or arrests the disease process. In spite of many shortcomings in the published data, penicillin is safe and free of severe reactions. Most authors agree that significant subjective improvement in the patient's status occurs following penicillin treatment. Once the patient has become symptomatic penicillin may have little efficacy. The optimal dosage and duration of therapy have never been established. Because of its low cost, ease of administration, and lack of toxicity, it should be given to all patients with cardiovascular syphilis in hope of arresting the effects of the disease on the heart and great vessels.
回顾了关于用青霉素治疗心血管梅毒的英文文献。迄今为止，尚无对照随机临床试验证明青霉素疗法能延长预期寿命、缓解症状或阻止疾病进程。尽管已发表的数据存在许多缺陷，但青霉素是安全的，且无严重不良反应。大多数作者一致认为，青霉素治疗后患者状况会有显著的主观改善。一旦患者出现症状，青霉素可能疗效甚微。治疗的最佳剂量和疗程从未确定。由于其成本低、易于给药且无毒，应给予所有心血管梅毒患者，以期阻止疾病对心脏和大血管的影响。
