ML-236A、ML-236B和ML-236C，由桔青霉产生的新型胆固醇生物合成抑制剂。 - Suppr

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ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium.

作者信息

Endo A, Kuroda M, Tsujita Y

出版信息

J Antibiot (Tokyo). 1976 Dec;29(12):1346-8. doi: 10.7164/antibiotics.29.1346.

DOI:10.7164/antibiotics.29.1346

PMID:1010803

Abstract

摘要

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ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium.ML-236A、ML-236B和ML-236C，由桔青霉产生的新型胆固醇生物合成抑制剂。

J Antibiot (Tokyo). 1976 Dec;29(12):1346-8. doi: 10.7164/antibiotics.29.1346.

Inhibition of cholesterol synthesis in vitro and in vivo by ML-236A and ML-236B, competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

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Biosynthesis of ML-236B (compactin) and monacolin K.ML-236B（美伐他汀）和莫纳可林K的生物合成

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Lack of correlation between the rate of cholesterol biosynthesis and the activity of 3-hydroxy-3-methylgutaryl coenzyme A reductase in rats and in fibroblasts treated with ML-236B.

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Isolation of compactin (a hypocholestrolemic metabolite) from a new source: Penicillium cyclopium.

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Compactin (ML-236B) and related compounds as potential cholesterol-lowering agents that inhibit HMG-CoA reductase.美伐他汀（ML-236B）及相关化合物作为潜在的降胆固醇药物，可抑制HMG-CoA还原酶。

J Med Chem. 1985 Apr;28(4):401-5. doi: 10.1021/jm00382a001.

The effect of compactin, a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme-A reductase activity, on cholesterogenesis and serum cholesterol levels in rats and chicks.强效3-羟基-3-甲基戊二酰辅酶A还原酶活性抑制剂美伐他汀对大鼠和雏鸡胆固醇生成及血清胆固醇水平的影响。

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Cholesterol biosynthesis inhibitory component from Zingiber officinale Roscoe.

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Tissue-selective inhibition of cholesterol synthesis in vivo by pravastatin sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor.普伐他汀钠（一种3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂）对体内胆固醇合成的组织选择性抑制作用。

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