青霉胺对小鼠脑内维生素B6各组分含量的影响。

Effects of penicillamine on the contents of B6 vitamers of the mouse brain.

作者信息

Takahashi Y, Matsuda M

出版信息

J Nutr Sci Vitaminol (Tokyo). 1976;22(5):375-9. doi: 10.3177/jnsv.22.375.

DOI:10.3177/jnsv.22.375

Abstract

The contents of B6 vitamers were measured in the brains of mice treated with DL- and D-PeA. When a single convulsant dose of DL-PeA was injected, PLP content was decreased, being accompanied with production of PLP-thiazolidine. The effect of DL-PeA on PLP content was evident far before the occurrence of the convulsions. The administration of PN together with DL-PeA prevented the onset of seizures and lessened the effect of DL-PeA on PLP content. The same amount of D-PeA did not invoke seizures, but caused a small but significant decrease in PLP content.

摘要

在接受DL - 青霉胺（DL - PeA）和D - 青霉胺（D - PeA）处理的小鼠大脑中测定了B6维生素类物质的含量。当注射单剂量惊厥性的DL - PeA时，磷酸吡哆醛（PLP）含量降低，并伴有磷酸吡哆醛 - 噻唑烷的产生。DL - PeA对PLP含量的影响在惊厥发作之前就很明显。与DL - PeA一起给予吡哆醇（PN）可预防癫痫发作，并减轻DL - PeA对PLP含量的影响。相同剂量的D - PeA不会引发癫痫发作，但会导致PLP含量出现轻微但显著的下降。