• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Pharmacokinetics of carbamazepine in normal humans after single and repeated oral doses.

作者信息

Géradin A P, Abadie F V, Campestrini J A, Theobald W

出版信息

J Pharmacokinet Biopharm. 1976 Dec;4(6):521-35. doi: 10.1007/BF01064556.

DOI:10.1007/BF01064556
PMID:1011076
Abstract
摘要

相似文献

1
Pharmacokinetics of carbamazepine in normal humans after single and repeated oral doses.卡马西平单次及多次口服给药后在正常人体内的药代动力学
J Pharmacokinet Biopharm. 1976 Dec;4(6):521-35. doi: 10.1007/BF01064556.
2
Distribution and elimination kinetics of carbamazepine in man.卡马西平在人体内的分布与消除动力学
Eur J Clin Pharmacol. 1975 Feb 28;8(2):91-6. doi: 10.1007/BF00561556.
3
The pharmacokinetics of carbamazepine in plasma and saliva of man.
Acta Pharmacol Toxicol (Copenh). 1977 Nov;41(5):465-71. doi: 10.1111/j.1600-0773.1977.tb02157.x.
4
The pharmacokinetics of carbamazepine.
Eur J Clin Pharmacol. 1977 Dec 28;12(6):451-6. doi: 10.1007/BF00561065.
5
[Efficient serum concentrations after single doses of antiepileptic drugs: concept of loading-dose].[单次剂量抗癫痫药物后的有效血清浓度：负荷剂量的概念]
Arq Neuropsiquiatr. 1985 Mar;43(1):11-6. doi: 10.1590/s0004-282x1985000100002.
6
Secretion of human growth hormone and insulin in levodopa test during carbamazepine therapy.
Acta Pharmacol Toxicol (Copenh). 1977 Feb;40(2):285-8. doi: 10.1111/j.1600-0773.1977.tb02080.x.
7
Interaction of carbamazepine and phenobarbital in rabbits.卡马西平与苯巴比妥在兔体内的相互作用。
Biomed Chromatogr. 2000 Aug;14(5):344-8. doi: 10.1002/1099-0801(200008)14:5<344::AID-BMC994>3.0.CO;2-E.
8
Pharmacokinetics of carbamazepine in monkeys following intravenous and oral administration.卡马西平经静脉和口服给药后在猴体内的药代动力学。
J Pharm Sci. 1975 Feb;64(2):302-7. doi: 10.1002/jps.2600640224.
9
Plasma kinetics of carbamazepine and its epoxide metabolite in man after single and multiple doses.卡马西平及其环氧化物代谢产物在人体单次和多次给药后的血浆动力学
Eur J Clin Pharmacol. 1975 Jun 13;8(5):337-41. doi: 10.1007/BF00562659.
10
Bioequivalence of oral and intravenous carbamazepine formulations in adult patients with epilepsy.成人癫痫患者口服和静脉注射卡马西平制剂的生物等效性。
Epilepsia. 2015 Jun;56(6):915-23. doi: 10.1111/epi.13012. Epub 2015 May 16.

引用本文的文献

1
Applying Physiologically Based Pharmacokinetic Modeling to Interpret Carbamazepine's Nonlinear Pharmacokinetics and Its Induction Potential on Cytochrome P450 3A4 and Cytochrome P450 2C9 Enzymes.应用基于生理的药代动力学模型解释卡马西平的非线性药代动力学及其对细胞色素P450 3A4和细胞色素P450 2C9酶的诱导潜力。
Pharmaceutics. 2024 May 30;16(6):737. doi: 10.3390/pharmaceutics16060737.
2
Animal-free assessment of developmental toxicity: Combining PBPK modeling with the ReproTracker assay.无动物评估发育毒性：结合 PBPK 模型与 ReproTracker 检测。
Toxicology. 2023 Dec;500:153684. doi: 10.1016/j.tox.2023.153684. Epub 2023 Nov 27.
3

本文引用的文献

1
Per cent absorbed time plots derived from blood level and/or urinary excretion data.根据血药浓度和/或尿排泄数据得出的吸收百分比-时间曲线图。
J Pharm Sci. 1963 Jun;52:610-1. doi: 10.1002/jps.2600520629.
2
Preliminary observations of serum carbamazepine concentration in epileptic patients.
Neurology. 1973 Apr;23(4):357-66. doi: 10.1212/wnl.23.4.357.
3
Concentration of carbamazepine (Tegretol) in serum and in cerebrospinal fluid in patients with epilepsy.
Epilepsia. 1973 Dec;14(4):373-9. doi: 10.1111/j.1528-1157.1973.tb03976.x.
4
Integration of Biorelevant Pediatric Dissolution Methodology into PBPK Modeling to Predict In Vivo Performance and Bioequivalence of Generic Drugs in Pediatric Populations: a Carbamazepine Case Study.
将生物相关儿科溶出度方法学整合到 PBPK 建模中，以预测儿科人群中仿制药的体内性能和生物等效性：卡马西平案例研究。
AAPS J. 2023 Jun 29;25(4):67. doi: 10.1208/s12248-023-00826-1.
4
Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug-Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach.CYP3A4和CYP2B6诱导剂卡马西平的药代动力学及其药物相互作用潜力：基于生理的药代动力学建模方法
Pharmaceutics. 2021 Feb 17;13(2):270. doi: 10.3390/pharmaceutics13020270.
5
Investigating Oral Absorption of Carbamazepine in Pediatric Populations.研究卡马西平在儿科人群中的口服吸收情况。
AAPS J. 2017 Nov;19(6):1864-1877. doi: 10.1208/s12248-017-0149-6. Epub 2017 Oct 2.
6
Bioequivalence of oral and intravenous carbamazepine formulations in adult patients with epilepsy.成人癫痫患者口服和静脉注射卡马西平制剂的生物等效性。
Epilepsia. 2015 Jun;56(6):915-23. doi: 10.1111/epi.13012. Epub 2015 May 16.
7
Differential effects on fast and slow spindle activity, and the sleep slow oscillation in humans with carbamazepine and flunarizine to antagonize voltage-dependent Na+ and Ca2+ channel activity.卡马西平和氟桂利嗪拮抗电压依赖性钠和钙通道活性对人类快、慢纺锤波活动和睡眠慢波振荡的差异作用。
Sleep. 2013 Jun 1;36(6):905-11. doi: 10.5665/sleep.2722.
8
Steady-state carbamazepine pharmacokinetics following oral and stable-labeled intravenous administration in epilepsy patients: effects of race and sex.癫痫患者口服和静脉内稳定标记后卡马西平的药代动力学稳态：种族和性别的影响。
Clin Pharmacol Ther. 2012 Mar;91(3):483-8. doi: 10.1038/clpt.2011.251. Epub 2012 Jan 25.
9
Pharmacological modulation of cortical excitability shifts induced by transcranial direct current stimulation in humans.人类经颅直流电刺激诱导的皮质兴奋性变化的药理学调节。
J Physiol. 2003 Nov 15;553(Pt 1):293-301. doi: 10.1113/jphysiol.2003.049916. Epub 2003 Aug 29.
10
Pharmacokinetics of carbamazepine. Part I: A new bioequivalency parameter based on a relative bioavailability trial.
Eur J Drug Metab Pharmacokinet. 1994 Oct-Dec;19(4):319-25. doi: 10.1007/BF03188858.
Distribution and elimination kinetics of carbamazepine in man.卡马西平在人体内的分布与消除动力学
Eur J Clin Pharmacol. 1975 Feb 28;8(2):91-6. doi: 10.1007/BF00561556.
5
GLC determination of carbamazepine suitable for pharmacokinetic studies.
J Pharm Sci. 1975 Dec;64(12):1940-2. doi: 10.1002/jps.2600641206.
6
Pharmacokinetics of carbamazepine in normal man.卡马西平在正常人体内的药代动力学。
Clin Pharmacol Ther. 1975 Jun;17(6):657-68. doi: 10.1002/cpt1975176657.