Bernardis L L, Goldman J K
J Neurosci Res. 1976;2(4):291-8. doi: 10.1002/jnr.490020406.
Weanling male Sprague-Dawley rats received bilateral electrolytic lesions in the dorsomedial hypothalamic area by means of a direct cathodal current. Sham-operated rats served as controls. Ponderal and linear growth, obesity index, food intake, and several indices of intermediary metabolism of adipose tissue and muscle were measured. Cathodal lesions, as did anodal lesions reported on previously resulted in retardation of body weight, length, and food intake, while the obesity index remained in the normal range. Similarly, the metabolic data in adipose tissue and muscle are comparable to those from experiments in which dorsomedial lesions were placed by anodal current: incorporation of glucose into CO2 lipid, and glycogen of muscle tissue (diaphragm) were similar in DMN-lesioned rats and controls. The difference between anodal and cathodal lesions in this hypothalamic syndrome is a delay in the onset of hypophagia until about 30 days after the hypothalamic operation. The data support the concept that lesions in the hypothalamus, in general, exert their effect by destruction of neuronal assemblies, i.e., nerve cells and/or fiber tracts passing through the lesioned area.
对断乳雄性斯普拉格-道利大鼠通过直接阴极电流在双侧下丘脑背内侧区造成电解损伤。假手术大鼠作为对照。测量了体重、体长、肥胖指数、食物摄入量以及脂肪组织和肌肉中间代谢的几个指标。阴极损伤与先前报道的阳极损伤一样，导致体重、体长和食物摄入量的增长迟缓，而肥胖指数仍在正常范围内。同样，脂肪组织和肌肉的代谢数据与通过阳极电流在下丘脑背内侧造成损伤的实验数据相当：在双侧下丘脑背内侧核损伤大鼠和对照组中，肌肉组织（膈肌）中葡萄糖转化为二氧化碳、脂质和糖原的情况相似。在这种下丘脑综合征中，阳极损伤和阴极损伤之间的差异在于摄食减少的起始时间延迟至下丘脑手术后约30天。这些数据支持这样的观点，即一般来说，下丘脑损伤是通过破坏神经元集合体（即神经细胞和/或穿过损伤区域的纤维束）来发挥其作用的。
