Goldman J K, Bernardis L L, MacKenzie R G, Kodis M, Luboshitzky R
Diabetologia. 1981 Mar;20 Suppl:357-61.
In weanling male rats, destruction of the ventromedial hypothalamus causes increased carcass lipid deposition and decreased linear growth without changes in food intake or blood glucose levels. These changes are not dependent on altered pituitary function. Lipogenesis and glucose utilization are increased in vivo and in vitro, while gluconeogenesis is accelerated in vivo. The enhanced lipogenesis occurs before increased gluconeogenesis.
在断乳雄性大鼠中，腹内侧下丘脑的破坏会导致胴体脂质沉积增加和线性生长减少，而食物摄入量或血糖水平没有变化。这些变化不依赖于垂体功能的改变。体内和体外的脂肪生成及葡萄糖利用均增加，而体内糖异生加速。脂肪生成增强发生在糖异生增加之前。
