Garnham J C, Raymond K, Shotton E, Turner P
J Trop Med Hyg. 1976 Dec;79(12):264-9.
Plain tablets of quinine dihydrochloride, quinine bisulphate and quinine sulphate was prepared using salts of similar particle size. Proprietary sugar-coated tablets showed protracted disintegration and dissolution using dialysis method with forced convection and sink conditions was as anticipated by the solubilities. In vivo availability studies indicated release from the plain tablets in the order dihydrochloride, bisulphate, sulphate. The sugar-coated tablets showed delayed release and corresponding low availability
使用粒径相似的盐制备了二盐酸奎宁、硫酸氢奎宁和硫酸奎宁的普通片剂。通过强制对流和漏槽条件下的透析法研究发现，专利糖衣片的崩解和溶解过程延长，这与溶解度预期一致。体内可用性研究表明，普通片剂的释放顺序为二盐酸盐、硫酸氢盐、硫酸盐。糖衣片显示出延迟释放以及相应的低可用性。
