Warburton A, Royston J P, O'Neill C J, Nicholson P W, Jee R D, Denham M J, Dobbs S M, Dobbs R J
Br J Clin Pharmacol. 1987 Apr;23(4):459-65. doi: 10.1111/j.1365-2125.1987.tb03076.x.
A double-blind, placebo-controlled, cross-over trial of quinine in leg cramps occurring at rest was conducted in 22 elderly cramp sufferers. Despite demonstration of impaired quinine elimination in the elderly, prescription of the traditional dose of 300 mg quinine bisulphate at night failed to produce a significant (P = 0.1) reduction in the number or severity of cramps. There was a significant relationship between serum quinine concentration and attenuation of cramps. However, the simple expedient of increasing the nightly dose of quinine may carry the concomitant risk of cinchonism.
对22名老年腿部抽筋患者进行了一项双盲、安慰剂对照、交叉试验，以研究奎宁对静息时腿部抽筋的疗效。尽管已证明老年人奎宁清除能力受损，但夜间服用传统剂量300毫克硫酸奎宁未能显著（P = 0.1）减少抽筋的次数或严重程度。血清奎宁浓度与抽筋减轻之间存在显著关系。然而，简单地增加奎宁夜间剂量可能会带来金鸡纳中毒的风险。
