Astakhova T A, Kaĭnova A S, Sigidin Ia A
Kardiologiia. 1976 Nov;16(11):133-6.
In patients with active rheumatism the activity of the key enzymes of the pentose cycle -- glucoso-6-phosphatedehydrogenase and transketolase -- increases in the erythrocytes of the peripheral blood parallel with the severity of the inflammatory lesion of the heart. In patients with distrophic changes in the myocardium without concomitant carditis the level of glucoso-6-phosphatedehydrogenase did not change significantly, while the content of transketolase decreased considerably. Antirheumatic therapy helping to reduce the inflammatory reactions in the heart results in a reduction of the level of pentose cycle enzymes. The study of the ratio between glucoso-6-phosphatedehydrogenase and transketolase may prove valuable for an approximate evaluation of the predominance of inflammatory or dystrophic processes in the cardiac muscle.
在活动性风湿病患者中，外周血红细胞中戊糖循环的关键酶——葡萄糖-6-磷酸脱氢酶和转酮醇酶的活性随着心脏炎症病变的严重程度而升高。在心肌发生营养不良性改变而无并发心肌炎的患者中，葡萄糖-6-磷酸脱氢酶水平无明显变化，而转酮醇酶含量则显著降低。有助于减轻心脏炎症反应的抗风湿治疗会使戊糖循环酶水平降低。研究葡萄糖-6-磷酸脱氢酶与转酮醇酶之间的比例，对于大致评估心肌中炎症或营养不良过程的优势可能具有重要价值。
